Sympathetic Reinnervation 1 Year After Heart Transplantation, Assessed Using Iodine-123 Metaiodobenzylguanidine Imaging
Sympathetic Reinnervation 1 Year After Heart Transplantation, Assessed Using Iodine-123 Metaiodobenzylguanidine Imaging
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DOI：
10.1016/j.transproceed.2011.05.020
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发表时间：
2011-07-01
影响因子：
0.9
通讯作者：
Salvador, A.
中科院分区：
文献类型：
--
作者：
Buendia-Fuentes, F.;Almenar, L.;Salvador, A.
在心脏移植（HT）过程中发生完全的同种异体移植物去神经。移植后可能发生的部分心室交感神经再支配可以使用碘-123 Meta碘苄胍（MIBG）摄取来测量。以前的研究表明，神经再支配可能是一个缓慢的过程，仅发生在移植后1年。然而，HT后1年的神经再支配患病率仍然未知。本研究旨在确定术后12个月时通过MIBG测量的交感神经再支配。我们对45例心脏移植受者，包括32例男性和13例女性，在术后早期（2个月）和晚期（12个月）进行了连续心脏MIBG显像。心肌摄取MIBG的强度通过心脏与纵隔比率（HMR）进行定量。当HMR> 1.3时，考虑神经再支配。12个月时HMR显著更高：2个月时为1.16 +/- 0.10，12个月时为1.30 +/- 0.15（P < .001）。45名受试者中的18名（40%）在移植后1年出现可见的心脏MIBG摄取，HMR > 1.3。总之，部分交感神经再支配随着HT后时间的推移而增加;在术后1年时，有40%的患者发生了交感神经再支配。
Complete allograft denervation occurs during heart transplantation (HT). Partial ventricular sympathetic reinnervation that may develop after transplantation can be measured using iodine-123 meta iodobenzylguanidine (MIBG) uptake. Previous studies have suggested that reinnervation is likely to be a slow process, only occurring after 1 year posttransplantation. However, the reinnervation prevalence at 1 year after HT remains unknown. This study sought to determine sympathetic reinnervation measured by MIBG at 12 months after surgery. We performed serial cardiac MIBG imaging in 45 cardiac transplant recipients, including 32 males and 13 females, early (2 months) and late (12 months) after the operation. The intensity of myocardial MIBG uptaken was quantified by heart-to-mediastinum ratios (HMR). Reinnervation was considered when the HMR was > 1.3. HMR was significantly higher at 12 months: 1.16 +/- 0.10 at 2 vs 1.30 +/- 0.15 at 12 months (P < .001). Eighteen (40%) of 45 subjects developed visible cardiac MIBG uptake at 1 year after transplantation with HMR > 1.3. In conclusion, partial sympathetic reinnervation increases with time after HT; it was seen in 40% of patients at 1 year after the operation.