Cumulative Endogenous Estrogen Exposure Is Associated With Postmenopausal Fracture Risk: The Women's Health Initiative Study.
Cumulative Endogenous Estrogen Exposure Is Associated With Postmenopausal Fracture Risk: The Women's Health Initiative Study.
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累积内源性雌激素暴露与绝经后骨折风险相关：妇女健康倡议研究。
DOI：
10.1002/jbmr.4613
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发表时间：
2022-07
影响因子：
6.2
通讯作者：
Crandall, Carolyn J.
中科院分区：
文献类型：
--
作者：
LeBlanc, Erin S.;Hovey, Kathleen M.;Cauley, Jane A.;Stefanick, Marcia;Peragallo, Rachel;Naughton, Michelle J.;Andrews, Christopher A.;Crandall, Carolyn J.
我们的目的是评估150，682名参与妇女健康倡议的绝经后妇女（基线年龄为50至79岁）的累积内源性雌激素暴露与骨折风险之间的关系。我们假设，特征表明较低的累积内源性雌激素暴露与骨折风险增加有关。我们从基线调查问卷中确定了初潮和绝经的年龄以及月经不规律的病史，并从初潮和绝经的年龄计算了内源性雌激素暴露的年数。在平均16.7年的随访中，自我报告了临床骨折事件。我们使用多变量比例风险模型来评估雌激素相关变量与任何临床骨折发生率之间的相关性。在完全校正的模型中，与内源性雌激素暴露时间为36 - 40年的女性（参考类别）相比，内源性雌激素暴露时间最短的女性（<30年）发生中央体骨折的风险高11%，下肢骨折的风险高9%。相反，内源性雌激素暴露最多的女性（超过45年）下肢骨折的风险比参考类别低9%。月经周期不规则（非每月）的女性比月经周期规则的女性发生下肢骨折的可能性高7%至8%。我们的研究结果支持这一假设，即特征标志着较低的累积内源性雌激素暴露与较高的骨折风险。
We aimed to evaluate the relationship between cumulative endogenous estrogen exposure and fracture risk in 150,682 postmenopausal women (aged 50 to 79 years at baseline) who participated in the Women’s Health Initiative. We hypothesized that characteristics indicating lower cumulative endogenous estrogen exposure would be associated with increased fracture risk. We determined ages at menarche and menopause as well as history of irregular menses from baseline questionnaires and calculated years of endogenous estrogen exposure from ages at menarche and menopause. Incident clinical fractures were self-reported over an average 16.7 years of follow-up. We used multivariable proportional hazards models to assess the associations between the estrogen-related variables and incidence of any clinical fracture. In fully adjusted models, those with the fewest years of endogenous estrogen exposure (<30) had an 11% higher risk of developing central body fractures and a 9% higher risk of lower extremity fractures than women with 36 to 40 years of endogenous estrogen exposure (the reference category). In contrast, women with the most years of endogenous estrogen exposure (more than 45 years) had a 9% lower risk of lower extremity fractures than the reference category. Women with irregular (not monthly) menstrual cycles were 7% to 8% more likely to experience lower extremity fractures than women with regular monthly cycles. Our findings support the hypothesis that characteristics signifying lower cumulative endogenous estrogen exposure are associated with higher fracture risk.
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影响因子：
5.4
作者：
Ley SH;Li Y;Tobias DK;Manson JE;Rosner B;Hu FB;Rexrode KM
通讯作者：
Rexrode KM
影响因子：
4.1
作者：
Dennison EM;Compston JE;Flahive J;Siris ES;Gehlbach SH;Adachi JD;Boonen S;Chapurlat R;Díez-Pérez A;Anderson FA Jr;Hooven FH;LaCroix AZ;Lindsay R;Netelenbos JC;Pfeilschifter J;Rossini M;Roux C;Saag KG;Sambrook P;Silverman S;Watts NB;Greenspan SL;Premaor M;Cooper C;GLOW Investigators
通讯作者：
GLOW Investigators
影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL
初潮中自我报告的年龄的可重复性：Tromsø研究。
DOI：
10.1186/s12905-017-0420-0
发表时间：
2017-08-22
期刊：
BMC women's health
影响因子：
--
作者：
Lundblad MW;Jacobsen BK
通讯作者：
Jacobsen BK
DOI：
10.1002/mds.28760
发表时间：
2021-10
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Kusters CDJ;Paul KC;Duarte Folle A;Keener AM;Bronstein JM;Bertram L;Hansen J;Horvath S;Sinsheimer JS;Lill CM;Ritz BR
通讯作者：
Ritz BR