A 3-D hexagonal inverse micellar lyotropic phase.
A 3-D hexagonal inverse micellar lyotropic phase.
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DOI：
10.1021/ja809280r
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发表时间：
2009-02
影响因子：
15
通讯作者：
G. Shearman;A. Tyler;N. Brooks;R. Templer;O. Ces;R. V. Law;J. Seddon
中科院分区：
文献类型：
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作者：
G. Shearman;A. Tyler;N. Brooks;R. Templer;O. Ces;R. V. Law;J. Seddon
在细胞膜中发现的脂质在水的存在下形成各种自组装相。这些结构中的许多是液晶的，其结构基序反映在细胞和细胞器中，并且可以用于药物和基因的递送。本文报道了一种溶致液晶相的发现，它是基于三维六方密排反胶束结构，空间群为P6（3）/mmc。这是二十年来报道的第一个新的反溶致液晶相，并且是唯一已知的其结构由相同的反胶束的紧密堆积组成的溶致相。
Lipids that are found in cell membranes form a variety of self-assembled phases in the presence of water. Many of these structures are liquid-crystalline with structural motifs mirrored in cells and organelles and can be exploited in the delivery of drugs and genes. We report the discovery of a lyotropic liquid crystalline phase based on a 3-D hexagonal close-packed arrangement of inverse micelles, of space group P6(3)/mmc. This is the first new inverse lyotropic liquid-crystalline phase to be reported for two decades and is the only known lyotropic phase whose structure consists of a close packing of identical inverse micelles.