Modified th2 responses at high-dose exposures to allergen - Using an occupational model
Modified th2 responses at high-dose exposures to allergen - Using an occupational model
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DOI：
10.1164/rccm.200506-964oc
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发表时间：
2006-07-01
影响因子：
24.7
通讯作者：
Jones, Meinir
中科院分区：
文献类型：
--
作者：
Jeal, Hayley;Draper, Adrian;Jones, Meinir
原理：过敏原暴露与过敏和哮喘之间的关系是复杂的。猫变应原的高暴露水平与免疫球蛋白和免疫球蛋白(4)特异性抗体反应有关，没有致敏作用或哮喘风险，这一过程被描述为“改良的Th2反应”。在对儿童和职业性哮喘的纵向研究中，高暴露水平下过敏和哮喘的风险有所降低。目的：使用职业模型，调查估计的空气变应原暴露、特异性IgE、Ig G和Ig G(4)抗体的产生以及相关症状的患病率之间的关系。方法：对英国6个制药厂的工作场所暴露于老鼠的员工进行横断面调查。共有689人(89%)提供了血样并完成了问卷调查。测量和主要结果：在暴露于大鼠的最高水平时，对致敏和症状的暴露反应减弱。相反，产生大量特异性免疫球蛋白和免疫球蛋白4的个体的频率随着暴露强度的增加而增加。处理数量最多的大鼠的免疫球蛋白(4)/免疫球蛋白E比值最高。与只产生特异性IgE和IgG4的人相比，同时产生特异性IgE和IgG4的人发生与工作相关的胸部症状的风险较低。结论：高暴露于大鼠与特异性IgE和症状的发生率较低有关，但高特异性免疫球蛋白和免疫球蛋白(4)产生的频率增加。与单独产生特定的免疫球蛋白E相比，与单独产生特定的免疫球蛋白相比，与单独产生特定的免疫球蛋白相比，联合产生特定的免疫球蛋白可能会降低出现与工作相关的胸部症状的风险。
Rationale: The relationships between allergen exposures and allergy and asthma are complex. High exposure levels to cat allergen are associated with IgG- and IgG(4)-specific antibody responses without sensitization or risk of asthma, a process described as a "modified Th2 response." Attenuation of risk of allergy and asthma at high exposure levels has been reported in longitudinal studies of both childhood and occupational asthma.Objectives:To investigate, using an occupational model, the relationships among estimated exposure to aeroallergens, the production of specific IgE, IgG and IgG(4) antibodies, and the prevalence of associated symptoms.Methods: Cross-sectional survey of employees exposed to rats at work on six pharmaceutical sites across the United Kingdom. A total of 689 (89%) provided a blood sample and completed a questionnaire. Measurements and Main Results: At highest exposure to rats, there was an attenuation of the exposure response for sensitization and symptoms. In contrast, the frequency of individuals producing high quantities of specific IgG and IgG4 increased with exposure intensity. Ratios of IgG(4)/IgE were highest in those handling the greatest number of rats. Risk of developing work-related chest symptoms was lower for those who produced both specific IgE and IgG4 Compared to those with specific IgE only.Conclusions: High exposure to rats is associated with lower rates of specific IgE and symptoms but an increased frequency of high specific IgG and IgG(4) production. Specific IgG, produced together with specific IgE may reduce the risk of developing work-related chest symptoms compared with when specific IgE is produced alone.