Antifungal drug susceptibility of Cryptococcus neoformans from clinical sources in Nairobi, Kenya
Antifungal drug susceptibility of Cryptococcus neoformans from clinical sources in Nairobi, Kenya
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DOI：
10.1111/j.1439-0507.2006.01293.x
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发表时间：
2007-01-01
期刊：
影响因子：
4.9
通讯作者：
Kamiya, Shigeru
中科院分区：
文献类型：
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作者：
Bii, Christine C.;Makimura, Koichi;Kamiya, Shigeru
对80株肯尼亚新型隐球菌临床分离株的血清型和交配型进行了肉汤微量稀释对两性霉素B （AMP）、氟胞菌素、氟康唑（FLC）、伊曲康唑（ITC）和咪康唑（MCZ）的药敏试验。其中，80株中有75株为格鲁比变种（A型），80株中有3株（3.8%），2株为加蒂变种（B型）。交配实验证实所有分离株均为α交配型。78株（97.5%）具有最低抑菌浓度（MIC）
The serotypes and mating types of 80 clinical isolates of Cryptococcus neoformans from Kenya were studied and subjected to broth microdilution susceptibility testing to amphotericin B (AMP), flucytosin, fluconazole (FLC), itraconazole (ITC) and miconazole (MCZ). The isolates included C. neoformans var. grubii- 75 of 80 (serotype A; 93.7%), C. neoformans var. neoformans- three of 80 (3.8%) and C. neoformans var. gattii- two (serotype B; 2.5%). Mating experiment confirmed all the isolates to be alpha-mating type. Seventy-eight (97.5%) of the isolates had minimum inhibitory concentration (MIC) of