First report of autochthonous transmission of Zika virus in Brazil.
First report of autochthonous transmission of Zika virus in Brazil.
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DOI：
10.1590/0074-02760150192
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发表时间：
2015-06
影响因子：
2.8
通讯作者：
Luz K
中科院分区：
文献类型：
--
作者：
Zanluca C;Melo VC;Mosimann AL;Santos GI;Santos CN;Luz K
2015年初，巴西东北部报告了几例出现轻度发热、皮疹、结膜炎和关节痛症状的患者。虽然所有患者都生活在登革热流行区，但登革热的分子和血清学诊断结果均为阴性。基孔肯雅病毒感染也被丢弃。随后，通过逆转录-聚合酶链反应从8名患者的血清中检测到寨卡病毒（ZIKV），并通过DNA测序证实了结果。系统发育分析表明，所鉴定的ZIKV属于亚洲分支。这是巴西首次报告ZIKV感染。
In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.