New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus.
New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus.
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DOI：
10.1248/cpb.c15-00686
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发表时间：
2016-04
影响因子：
1.7
通讯作者：
Zhong-liu Zhou;Wen-qing Yin;Ya-Mei Yang;Chun-Hong He;Xiao-Na Li;Cui-Ping Zhou;Hong-Wei Guo
中科院分区：
文献类型：
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作者：
Zhong-liu Zhou;Wen-qing Yin;Ya-Mei Yang;Chun-Hong He;Xiao-Na Li;Cui-Ping Zhou;Hong-Wei Guo
根据活性筛选结果，从香附根茎中分离得到两个新的环烯醚萜苷类化合物，分别命名为rotundusideG（1）和rotundusideH（2），以及四个已知的环烯醚萜苷类化合物：Negundoside（3），nishindaside（4），isooleuropein（5）和nichuezenide（6）。根据文献和波谱方法鉴定了化合物的结构。在绝望的小鼠模型中，1和2显示出显著的抗抑郁活性。
Based on bioactive screening results, two new iridoid glycosides, named rotunduside G (1) and rotunduside H (2), were isolated from the rhizomes of Cyperus rotundus, together with four known ones, negundoside (3), nishindaside (4), isooleuropein (5) and neonuezhenide (6). Their structures were elucidated on the basis of spectroscopic methods and from literature values. In mice models of despair, 1 and 2 showed significant antidepressant activity.