Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects
Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects
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DOI：
10.1007/s12011-013-9701-0
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发表时间：
2013-07-01
影响因子：
3.9
通讯作者：
Koyama, Hiroshi
中科院分区：
文献类型：
--
作者：
Abdulah, Rizky;Noerjasin, Herlambang;Koyama, Hiroshi
硒是人体健康的必需营养素，据报道母体硒浓度与妊娠结局有关。为了进一步研究硒（Se）在流产中的可能作用，我们进行了一项病例对照研究，以评估硒水平、谷胱甘肽过氧化物酶活性与自然流产之间的相关性。选取46例正常妊娠妇女和25例自然流产妇女，分析其血清硒浓度和血清谷胱甘肽过氧化物酶活性。正常妊娠组血清总硒浓度显著高于自然流产组；然而，两组的谷胱甘肽过氧化物酶活性相似。我们进一步将受试者分为吸烟组和不吸烟组，logistic回归分析显示血清总硒浓度与流产发生率显著相关，而血清谷胱甘肽过氧化物酶活性或吸烟与流产发生率无显著相关。因此，本研究重申低血清硒水平与流产有关，硒在维持妊娠中起重要作用。
Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case-control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. A total of 46 subjects with normal pregnancies and 25 subjects with spontaneous abortion were recruited, and their serum selenium concentrations and serum glutathione peroxidase activities were analyzed. The total serum selenium concentrations in subjects with normal pregnancies were significantly higher than those of subjects with spontaneous abortion; however, the glutathione peroxidase activities were similar in both groups. We further separated the subjects into smoking and nonsmoking groups, and the logistic regression analysis suggested that total serum selenium concentration, but not serum glutathione peroxidase activity or smoking, was significantly correlated with the incidence of miscarriage. The present study thus reaffirms that low serum selenium levels are associated with miscarriage and that selenium plays an important role in pregnancy maintenance.