A Proposal for a Thyroid Imaging Reporting and Data System for Ultrasound Features of Thyroid Carcinoma
A Proposal for a Thyroid Imaging Reporting and Data System for Ultrasound Features of Thyroid Carcinoma
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DOI：
10.1089/thy.2008.0021
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发表时间：
2009-11-01
期刊：
影响因子：
6.6
通讯作者：
Kim, Seong Hun
中科院分区：
文献类型：
--
作者：
Park, Ji-Young;Lee, Hui Joong;Kim, Seong Hun
背景：多项甲状腺超声（TUS）发现与甲状腺癌风险增加有关；然而，对于 TUS 结果报告的格式和风格尚未达成共识。本研究的目的是根据 TUS 发现表明甲状腺结节恶性的特征，使用这些特征生成一个可预测甲状腺结节恶性的方程，并将该方程的结果分层到反映恶性概率的 TUS 类别中。 1694 名患者接受了超声引导下的细针抽吸活检。然后，我们根据 TUS 生成了一个方程来预测恶性肿瘤的概率，并开发了从最低到最高的恶性肿瘤概率的类别。我们使用有关甲状腺结节恶性肿瘤的细胞学和组织病理学信息评估了该方程和类别的可靠性。结果：我们对 TUS 上看到的甲状腺结节的 12 个方面进行了表征，并开发了一个方程来预测 P-us，即根据这些 US 结果预测结节恶性的概率。方程为P-us-1/(1+e(-z))，其中e是数学常数2.71828，z是甲状腺恶性结节的logit。根据结果显示的结节恶性概率，将 P-us 分为五类（TUS 1，良性；TUS 2，可能良性；TUS 3，不确定；TUS 4，可能恶性；TUS 5，恶性）。细胞学类别与 TUS 1 至 TUS 5 类别之间存在显着相关性 (r-0.491，p
Background: Several thyroid ultrasound (TUS) findings have been associated with an increased risk for thyroid cancer; however, there is no consensus as to the format and style for reporting the results of TUS. The objective of this study was to discover the features indicative of malignancy in thyroid nodules based on TUS, generate an equation using these features that would be predictive of malignancy in thyroid nodules, and stratify the results of this equation into TUS categories reflecting the probability of malignancy.Methods: We obtained odds ratios of TUS findings indicative of malignancy and probability of malignancy for each nodule as determined by logistic regression analysis of ultrasound (US) findings in 1694 patients who had US-guided fine-needle aspiration biopsy. We then generated an equation to predict the probability of malignancy based on TUS and developed categories ranging from lowest to highest probability of malignancy. We evaluated the reliability of this equation and the categories using cytology and histopathology information regarding malignancy in the thyroid nodules.Results: We characterized 12 aspects of thyroid nodules as seen on TUS and developed an equation to predict P-us, the probability of a nodule being malignant based on these US findings. The equation was P-us-1/(1+e(-z)), where e is the mathematical constant 2.71828 and z is the logit of malignant thyroid nodule. P-us was stratified into five categories based on the probability of a nodule being malignant as indicated by the findings ( TUS 1, benign; TUS 2, probably benign; TUS 3, indeterminate; TUS 4, probably malignant; TUS 5, malignant). There was a significant correlation between the cytological category and the TUS 1 through TUS 5 categories (r-0.491, p