Human excretion of bisphenol A: blood, urine, and sweat (BUS) study.
Human excretion of bisphenol A: blood, urine, and sweat (BUS) study.
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DOI：
10.1155/2012/185731
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发表时间：
2012
影响因子：
--
通讯作者：
Lobo RA
中科院分区：
文献类型：
--
作者：
Genuis SJ;Beesoon S;Birkholz D;Lobo RA
背景。双酚 A (BPA) 是一种普遍存在的化学污染物，最近被发现对人类健康产生不利影响。人们对 BPA 毒代动力学的了解还不完全，并且没有既定的干预措施来消除人体中的这种化合物。这项研究共有 20 名研究参与者，旨在评估三种体液（血液、尿液和汗液）中 BPA 的相对浓度，并确定诱导出汗是否可能是一种治疗干预措施，有可能促进消除这种化合物。方法。采集了 20 名个体（10 名健康参与者和 10 名有各种健康问题的参与者）的血液、尿液和汗液，并分析了包括 BPA 在内的各种环境毒物。结果。在血液、尿液和汗液中都发现了不同程度的 BPA。 20 名参与者中有 16 人在汗液中检测出了 BPA，甚至在一些血清或尿液样本中未检测到 BPA 的个体中也是如此。结论。通过血液和/或尿液检测对 BPA 进行生物监测可能会低估这种潜在毒物对身体的总体负担。汗液分析应被视为监测人体 BPA 生物累积的另一种方法。诱导出汗似乎是消除 BPA 的潜在方法。
Background. Bisphenol A (BPA) is an ubiquitous chemical contaminant that has recently been associated with adverse effects on human health. There is incomplete understanding of BPA toxicokinetics, and there are no established interventions to eliminate this compound from the human body. Using 20 study participants, this study was designed to assess the relative concentration of BPA in three body fluids—blood, urine, and sweat—and to determine whether induced sweating may be a therapeutic intervention with potential to facilitate elimination of this compound. Methods. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for various environmental toxicants including BPA. Results. BPA was found to differing degrees in each of blood, urine, and sweat. In 16 of 20 participants, BPA was identified in sweat, even in some individuals with no BPA detected in their serum or urine samples. Conclusions. Biomonitoring of BPA through blood and/or urine testing may underestimate the total body burden of this potential toxicant. Sweat analysis should be considered as an additional method for monitoring bioaccumulation of BPA in humans. Induced sweating appears to be a potential method for elimination of BPA.