Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides
Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides
复制标题
脂-α/磺基-γ-AA 杂合肽的抗菌活性
DOI：
10.1016/j.ejmech.2019.111901
复制
发表时间：
2020
影响因子：
6.7
通讯作者：
Cai, Jianfeng
中科院分区：
文献类型：
--
作者：
Wei, Lulu;Wang, Minghui;Gao, Ruixuan;Fatirkhorani, Rojin;Cai, Jianfeng
迫切需要开发新的抗菌药来对抗耐药。在这里，我们报道了一系列短小的Lipoo-α/磺化-γ-AA杂交肽的设计和合成。几个短肽对革兰氏阳性菌和革兰氏阴性菌都显示出强大的广谱抗菌活性。膜去极化和荧光显微镜研究表明，这些短小的Lipoo-α/磺化-γ-AA杂交肽可以模拟HDPs通过破坏细菌膜来杀灭细菌的机制。此外，这些短肽还显示出在极低浓度下消除大肠杆菌生物膜形成的能力。脂化α/磺胺-γ-AA杂交肽的进一步开发可能会导致一类新的抗药性药物的出现。
Development of novel antimicrobial agents combating drug resistance is in an urgent need. Herein we report the design and synthesis of a series of short lipo-α/sulfono-γ-AA hybrid peptides. Several short peptides exhibit potent and broad-spectrum antimicrobial activity toward both Gram-positive and Gram-negative bacteria. Membrane depolarization and fluorescence microscopy studies indicate that these short lipo-α/sulfono-γ-AA hybrid peptides can mimic the mechanisms of HDPs to kill bacteria by disrupting bacterial membranes. In addition, these short peptides also show capability to eradicate the biofilm formation ofE. colieven at very low concentration. The further development of lipidated α/sulofono-γ-AA hybrid peptides may lead to a new class of antibiotic agents to combat drug resistance.