Disability weights for the Global Burden of Disease 2013 study
Disability weights for the Global Burden of Disease 2013 study
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DOI：
10.1016/s2214-109x(15)00069-8
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发表时间：
2015-11-01
影响因子：
34.3
通讯作者：
Vos, Theo
中科院分区：
文献类型：
--
作者：
Salomon, Joshua A.;Haagsma, Juanita A.;Vos, Theo
全球疾病负担（GBD）研究使用残疾调整生命年评估疾病、伤害和风险因素造成的健康损失，这需要一组残疾权重来量化与非致命结局相关的健康水平。本研究的目的是估计GBD 2013研究的残疾权重。方法我们分析了在四个欧洲国家完成的18-65岁参与者的新网络调查数据（匈牙利、意大利、荷兰和瑞典）2013年9月23日至2013年11月11日期间，结合之前在GBD 2010残疾体重测量研究中收集的数据。调查使用配对比较问题，受访者认为两个假设的个人具有不同的健康状况，并指定他们认为哪个人比另一个更健康。这些调查涵盖了与2013年全球生物多样性日相关的183个健康状态;其中30个状态的描述是从以前的版本修订的，18个是2013年全球生物多样性日的新描述。我们使用概率单位回归分析对配对比较数据进行了分析，并将结果重新调整为0（没有健康损失）和1（损失等同于死亡）之间的残疾权重单位。我们比较结果与以前的估计，和额外的分析研究配对比较反应的敏感性，以持续时间的假设healthstates.Findings-总分析样本包括30 230名受访者从GBD 2010年的调查和30 660从新的欧洲调查。对于GBD 2010和GBD 2013常见的健康状态，结果总体上高度相关（Pearson（R）0.992 [95%不确定性区间0.989-0.994]）。对于本研究修订的健康状态描述，这些权重的子集（包括与听力损失相关的权重）产生的残疾权重有很大不同（例如，完全听力丧失：GBD 2010 0.033 [0.020-0.052]; GBD 2013 0.215 [0.144-0.307]）和经治疗的脊髓病变（颈部以下：GBD 2010 0.047 [0.028-0.072]; GBD 2013 0.296 [0.198-0.414];颈部水平：GBD 2010 0.369 [0.243-0.513]; GBD 2013 0.589 [0.415-0.748]）。调查对配对比较问题的反应不敏感，无论是在临时或长期的结果（皮尔逊（R）0.981 [0.973-0.987]）。解释这项研究大大扩展了GBD研究中的非致命性结果的评估的经验基础。这项研究的结果证实了残疾权重对健康状态描述中的特定细节敏感的概念，但对结果的持续时间很敏感。版权所有（C）Salomon等人。根据CC BY-NC-ND的条款分发的开放获取文章。
Background The Global Burden of Disease (GBD) study assesses health losses from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set of disability weights to quantify health levels associated with non-fatal outcomes. The objective of this study was to estimate disability weights for the GBD 2013 study.Methods We analysed data from new web-based surveys of participants aged 18-65 years, completed in four European countries (Hungary, Italy, the Netherlands, and Sweden) between Sept 23, 2013, and Nov 11, 2013, combined with data previously collected in the GBD 2010 disability weights measurement study. Surveys used paired comparison questions for which respondents considered two hypothetical individuals with different health states and specified which person they deemed healthier than the other. These surveys covered 183 health states pertinent to GBD 2013; of these states, 30 were presented with descriptions revised from previous versions and 18 were new to GBD 2013. We analysed paired comparison data using probit regression analysis and rescaled results to disability weight units between 0 (no loss of health) and 1 (loss equivalent to death). We compared results with previous estimates, and an additional analysis examined sensitivity of paired comparison responses to duration of hypothetical health states.Findings The total analysis sample consisted of 30 230 respondents from the GBD 2010 surveys and 30 660 from the new European surveys. For health states common to GBD 2010 and GBD 2013, results were highly correlated overall (Pearson's(R) 0.992 [95% uncertainty interval 0.989-0.994]). For health state descriptions that were revised for this study, resulting disability weights were substantially different for a subset of these weights, including those related to hearing loss (eg, complete hearing loss: GBD 2010 0.033 [0.020-0.052]; GBD 2013 0.215 [0.144-0.307]) and treated spinal cord lesions (below the neck: GBD 2010 0.047 [0.028-0.072]; GBD 2013 0.296 [0.198-0.414]; neck level: GBD 2010 0.369 [0.243-0.513]; GBD 2013 0.589 [0.415-0.748]). Survey responses to paired comparison questions were insensitive to whether the comparisons were framed in terms of temporary or chronic outcomes (Pearson's(R) 0.981 [0.973-0.987]).Interpretation This study substantially expands the empirical basis for assessment of non-fatal outcomes in the GBD study. Findings from this study substantiate the notion that disability weights are sensitive to particular details in descriptions of health states, but robust to duration of outcomes. Copyright (C) Salomon et al. Open Access article distributed under the terms of CC BY-NC-ND.