Urinary CXCL1: a novel predictor of IgA nephropathy progression.
Urinary CXCL1: a novel predictor of IgA nephropathy progression.
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DOI：
10.1371/journal.pone.0119033
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Zhao Y;Zhu L;Zhou T;Zhang Q;Shi S;Liu L;Lv J;Zhang H
伊加肾病（IgAN）是世界范围内最常见的原发性肾小球肾炎。近年来，人们一直在努力开发新的IgAN进展的非侵入性生物标志物。在我们之前的体外研究中，我们发现系膜衍生的CXCL 1是肾损伤的贡献者，并且观察到IgAN患者的尿CXCL 1水平较高。提示尿CXCL 1可能是一种潜在的生物标志物。本研究选取425例有随访资料的IgAN患者，检测其肾活检时尿CXCL 1水平，探讨尿CXCL 1对IgAN进展的预测价值。采用酶联免疫吸附试验测定尿CXCL 1水平。尿CXCL 1水平与目前已确定的IgAN进展预测因子相关，包括SBP（r = 0.138，p = 0.004），DBP（r = 0.114，p = 0.019），蛋白尿（r = 0.155，p = 0.001）、eGFR（r =-0.259，p<0.001）和肾小管萎缩和间质纤维化（r = 0.181，p<0.001）。校正后，尿CXCL 1水平升高与肾功能恶化风险增加独立相关（HR，每s.d.自然对数转换的CXCL 1增量：1.748; 95%CI：1.222-2.499，P = 0.002）。此外，时间依赖性受试者工作特征（ROC）曲线显示，尿CXCL 1与蛋白尿和eGFR结合时，可以增强这些传统预测因子对IgAN进展的预后价值。本研究结果提示尿CXCL 1可作为IgAN进展的一种新的非侵入性预测因子。
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. In recent years, consistent efforts have been made to develop new non-invasive biomarkers for IgAN progression. In our previous in vitro study we found mesangial derived CXCL1 as a contributor for kidney injury, and observed higher urinary CXCL1 levels in patients with IgAN. It implied that the urinary CXCL1 might be a potential biomarker. In the present study, we enrolled 425 IgAN patients with follow-up data and detected their urinary CXCL1 levels at the time of renal biopsy, to explore the predictive value of urinary CXCL1 in IgAN progression. Urinary CXCL1 levels were measured using enzyme-linked immunosorbent assay. Urinary CXCL1 levels were associated with presently well established predictors of IgAN progression, including SBP (r = 0.138, p = 0.004), DBP (r = 0.114, p = 0.019), proteinuria (r = 0.155, p = 0.001), eGFR (r = -0.259, p<0.001) and tubular atrophy and interstitial fibrosis (r = 0.181, p<0.001). After adjusted for them, higher levels of urinary CXCL1 were independently associated with a greater risk of deterioration in renal function (HR, per s.d. increment of natural log–transformed CXCL1: 1.748; 95% CI: 1.222–2.499, P = 0.002). Furthermore, time-dependent receiver operating characteristic (ROC) curve showed that urinary CXCL1, when combined with proteinuria and eGFR, could enhance the prognostic value of these traditional predictors for IgAN progression. The results in our present study suggested urinary CXCL1 as a new non-invasive predictor of IgAN progression.
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DOI：
10.2215/cjn.05950612
发表时间：
2013-07-01
影响因子：
9.8
作者：
Rocchetti, Maria Teresa;Papale, Massimo;Gesualdo, Loreto
通讯作者：
Gesualdo, Loreto
影响因子：
4.6
作者：
van der Veen, B. S.;Petersen, A. H.;Heeringa, P.
通讯作者：
Heeringa, P.
影响因子：
2.3
作者：
Chintakuntlawar, Ashish V.;Chodosh, James
通讯作者：
Chodosh, James
影响因子：
19.6
作者：
Roberts, Ian S. D.;Cook, H. Terence;Zhang, Hong
通讯作者：
Zhang, Hong
影响因子：
1.1
作者：
Stangou, Maria;Papagianni, Aikaterini;Memmos, Dimitrios
通讯作者：
Memmos, Dimitrios