White matter structural decline in normal ageing: A prospective longitudinal study using tract-based spatial statistics
White matter structural decline in normal ageing: A prospective longitudinal study using tract-based spatial statistics
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DOI：
10.1016/j.neuroimage.2010.02.033
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发表时间：
2010-06-01
期刊：
影响因子：
5.7
通讯作者：
Markus, Hugh S.
中科院分区：
文献类型：
--
作者：
Barrick, Thomas R.;Charlton, Rebecca A.;Markus, Hugh S.
正常的衰老伴随着认知功能的逐渐下降，但其机制尚未完全了解。尽管如此，白色变性的重要性得到了弥散张量成像（DTI）研究的支持，尽管关于与年龄相关的白色变性的模式和性质仍存在一些重要问题。首先，缺乏纵向数据来确定DTI参数随年龄的变化率，以及是否可以在短时间内检测到。其次，目前还不清楚所观察到的变化是否在整个大脑中是均匀的，或者加速的白色退化是否局限于特定的大脑区域，这将支持额叶老化假说。本研究使用DTI技术来量化结构完整性变化，以确定在50至90岁的健康中年和老年人样本的纵向随访期间退行性变率是否存在明显的区域差异。在分数各向异性，轴向和径向扩散率的纵向差异进行了研究，使用1D冠状切片配置文件，和2D柱图在标准空间，以及使用3D tract-based空间统计（TBSS），以调查局部年龄相关的结构变化体素的基础上，在基线和两年的随访。结果表明，DTI可以检测到年龄相关的变化，在白色物质结构在一个相对较短的随访期间，纵向分析显示显着的变化，白色物质完整性在整个大脑中，没有证据表明，在额叶区域加速下降，在2年的时间内。不同的扩散特性的共同变化进行了讨论。(C)2010年爱思唯尔公司All rights reserved.
Normal ageing is accompanied by a progressive decline in cognitive function but the mechanisms for this are not fully understood. Nevertheless, the importance of white matter degeneration is supported by diffusion tensor imaging (DTI) studies, although several important questions remain about the pattern and nature of age-related white matter degeneration. Firstly, there is a lack of longitudinal data determining the rate of change in DTI parameters with age, and whether this can be detected over short time periods. Secondly, it is unclear whether observed changes are uniform across the brain or whether accelerated white matter degeneration is localised to particular brain regions, as would support the frontal-ageing hypothesis. This study uses DTI techniques to quantify structural integrity change to determine whether regional differences are apparent in the rate of degeneration during longitudinal follow-up in a sample of healthy middle aged and older adults aged between 50 and 90 years. Longitudinal differences in fractional anisotropy, axial and radial diffusivity are investigated using 1D coronal slice profiles, and 2D column maps in standard space, as well as using 3D tract-based spatial statistics (TBSS) to investigate local age-related structural changes on a voxel-by-voxel basis at baseline and two-year follow-up. Results indicate that DTI can detect age-related change in white matter structure over a relatively short follow-up period and that longitudinal analyses reveal significant changes in white matter integrity throughout the brain with no evidence of accelerated decline in the frontal lobe regions during a 2 year period. Common changes across different diffusion characteristics are discussed. (C) 2010 Elsevier Inc. All rights reserved.