Environmentally Induced Epigenetic Transgenerational Inheritance and the Weismann Barrier: The Dawn of Neo-Lamarckian Theory.
Environmentally Induced Epigenetic Transgenerational Inheritance and the Weismann Barrier: The Dawn of Neo-Lamarckian Theory.
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DOI：
10.3390/jdb8040028
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发表时间：
2020-12-04
影响因子：
2.7
通讯作者：
Skinner MK
中科院分区：
文献类型：
--
作者：
Nilsson EE;Maamar MB;Skinner MK
在过去的120年里，Weismann屏障和相关的种质遗传理论已经成为影响进化生物学和我们通过种系遗传概念的学说。尽管奥古斯特·魏斯曼在他1872年的书中正确地指出，精子和卵子是将分子信息传递给后代的唯一细胞，但体细胞不影响生殖系（即魏斯曼屏障）的概念是不正确的。然而，魏斯曼屏障的学说或教条仍然影响着许多科学领域和主题。表观遗传学的发现，以及最近环境诱导的表型变异和病理的表观遗传跨代遗传，对今天的进化理论和医学产生了重大影响。环境表观遗传学和表观遗传跨代遗传的概念驳斥了Weismann障碍的某些方面，并要求对遗传理论和进化理论进行重新评估。
For the past 120 years, the Weismann barrier and associated germ plasm theory of heredity have been a doctrine that has impacted evolutionary biology and our concepts of inheritance through the germline. Although August Weismann in his 1872 book was correct that the sperm and egg were the only cells to transmit molecular information to the subsequent generation, the concept that somatic cells do not impact the germline (i.e., the Weismann barrier) is incorrect. However, the doctrine or dogma of the Weismann barrier still influences many scientific fields and topics. The discovery of epigenetics, and more recently environmentally induced epigenetic transgenerational inheritance of phenotypic variation and pathology, have had significant impacts on evolution theory and medicine today. Environmental epigenetics and the concept of epigenetic transgenerational inheritance refute aspects of the Weismann barrier and require a re-evaluation of both inheritance theory and evolution theory.
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影响因子：
64.8
作者：
Hajkova, Petra;Ancelin, Katia;Waldmann, Tanja;Lacoste, Nicolas;Lange, Ulrike C.;Cesari, Francesca;Lee, Caroline;Almouzni, Genevieve;Schneider, Robert;Surani, M. Azim
通讯作者：
Surani, M. Azim
影响因子：
64.5
作者：
Ashe A;Sapetschnig A;Weick EM;Mitchell J;Bagijn MP;Cording AC;Doebley AL;Goldstein LD;Lehrbach NJ;Le Pen J;Pintacuda G;Sakaguchi A;Sarkies P;Ahmed S;Miska EA
通讯作者：
Miska EA
影响因子：
3.7
作者：
Brieño-Enríquez MA;García-López J;Cárdenas DB;Guibert S;Cleroux E;Děd L;Hourcade Jde D;Pěknicová J;Weber M;Del Mazo J
通讯作者：
Del Mazo J
DOI：
10.1073/pnas.0906183107
发表时间：
2010-01-26
影响因子：
11.1
作者：
Feinberg, Andrew P.;Irizarry, Rafael A.
通讯作者：
Irizarry, Rafael A.
影响因子：
0.7
作者：
Bonnet-Garnier, Amelie;Feuerstein, Prisca;Beaujean, Nathalie
通讯作者：
Beaujean, Nathalie