Tnni3k influences cardiomyocyte S-phase activity and proliferation.
Tnni3k influences cardiomyocyte S-phase activity and proliferation.
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DOI：
10.1016/j.yjmcc.2023.08.004
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发表时间：
2023-08
影响因子：
5
通讯作者：
Alexandra L Purdy;Samantha K Swift;H. Sucov;Michaela Patterson
中科院分区：
文献类型：
--
作者：
Alexandra L Purdy;Samantha K Swift;H. Sucov;Michaela Patterson
心肌细胞增殖是一个很难捕捉和证明的现象。在这里，我们采用回顾性分析的单细胞心室悬浮液，以明确确定心肌细胞已完成细胞分裂。通过这种分析，我们确定心肌细胞在损伤后重新进入细胞周期和完成细胞分裂的能力是独立的和可变的特征。此外，我们提供的证据表明Tnni3k明确影响细胞周期的早期和晚期。
Cardiomyocyte proliferation is a difficult phenomenon to capture and prove. Here we employ a retrospective analysis of single cell ventricular suspensions to definitively identify cardiomyocytes that have completed cell division. Through this analysis we determined that the capacity of cardiomyocytes to re-enter the cell cycle and complete cell division after injury are separate and variable traits. Further, we provide evidence thatTnni3kdefinitively influences both early and final stages of the cell cycle.