A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch
A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch
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DOI：
10.1007/s10495-018-1499-y
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发表时间：
2019-02-01
期刊：
影响因子：
7.2
通讯作者：
Wu, Jianzhang
中科院分区：
文献类型：
--
作者：
Chen, Liping;Weng, Bixia;Wu, Jianzhang
细胞凋亡是一种新的细胞死亡方式，可由化疗药物介导。在抗肿瘤研究和化疗药物领域，人们对细胞凋亡的认识显著增加。因此，抑制肿瘤细胞凋亡是肺癌治疗的一个诱人的前景。在此，获得作为噻喃衍生物的化合物L 61 H10以比较其与姜黄素的活性。结果表明，L 61 H10在体内外均表现出较好的抗肿瘤活性，其抗肿瘤活性的机制可能与NF-B信号通路有关。此外，L 61 H10在体内外均无明显毒副作用。总之，L 61 H10是一种潜在的抗肺癌药物，其抗肿瘤机制的研究为化疗药物的研究提供了新的信息。
Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-B signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.