Intermittent claudication. A risk profile from The Framingham Heart Study.
Intermittent claudication. A risk profile from The Framingham Heart Study.
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DOI：
10.1161/01.cir.96.1.44
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发表时间：
1997-07
期刊：
影响因子：
37.8
通讯作者：
Joanne M. Murabito;Ralph B. D’Agostino;H. Silbershatz;Peter W.F. Wilson
中科院分区：
文献类型：
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作者：
Joanne M. Murabito;Ralph B. D’Agostino;H. Silbershatz;Peter W.F. Wilson
间歇性跛行是指死亡和残疾风险增加的人。方法和结果使用38年的随访数据为原始队列在心脏研究，我们开发了间歇性跛行的风险概况。共有381名男性和女性发生间歇性跛行。年龄、性别、血清胆固醇、高血压、吸烟、糖尿病和冠心病与跛行风险增加相关，并被纳入分析。使用一个合并的逻辑回归模型来计算特定风险因素水平下间歇性跛行的概率。结论：间歇性跛行的风险特征使医生能够在常规门诊中识别高风险个体，并可用于教育患者可改变的风险因素，特别是吸烟和血压。改善风险因素修改策略的依从性可能对生存率产生有益影响。
BACKGROUND Intermittent claudication identifies persons at increased risk for death and disability. METHODS AND RESULTS Using 38-year follow-up data for the original cohort in the Framingham Heart Study, we developed an intermittent claudication risk profile. Intermittent claudication occurred in a total of 381 men and women. Age, sex, serum cholesterol, hypertension, cigarette smoking, diabetes, and coronary heart disease were associated with an increased risk for claudication and were included in the profile. A pooled logistic regression model was used to compute the probability of intermittent claudication for specified levels of risk factors. CONCLUSIONS The intermittent claudication risk profile allows physicians to identify high-risk individuals during a routine office visit and can be used to educate patients about modifiable risk factors, particularly smoking and blood pressure. Improved compliance with risk factor modification strategies may result in a beneficial impact on survival.