Synergistic effects of anionic surfactants on coronavirus (SARS-CoV-2) virucidal efficiency of sanitizing fluids to fight COVID-19
Synergistic effects of anionic surfactants on coronavirus (SARS-CoV-2) virucidal efficiency of sanitizing fluids to fight COVID-19
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DOI：
10.1016/j.fct.2020.111702
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发表时间：
2020-11-01
影响因子：
4.3
通讯作者：
Avazpour, Arezoo
中科院分区：
文献类型：
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作者：
Jahromi, Reza;Mogharab, Vahid;Avazpour, Arezoo
我们周围的环境，特别是经常接触的污染表面，在社会中传播病原体方面发挥着重要作用。然而，在二零一九年十二月新型冠状病毒病（COVID-19）爆发后，有效消毒液的短缺迅速成为全球性挑战。在这项研究中，我们提出了表面活性剂对冠状病毒（SARS-CoV-2）杀菌效率的消毒液的影响。研究了十二烷基苯磺酸钠（SDBS）、月桂基聚氧乙烯醚硫酸钠（SLS）和两种市售洗洁精和洗手液，目的是降低消毒液的蒸发速率，以最大限度地延长表面接触时间。12个流体组成的不同配方的乙醇，异丙醇，SDBS，SLS，甘油，和水的标准硬度（WSH）的蒸发时间和杀病毒效率进行了测试。当向液体中加入表面活性剂时，蒸发时间增加17-63%。此外，根据EN 16615：2015欧洲标准方法中的4场测试，表面活性剂掺入将杀病毒效率提高了15%至27%。然而，最重要的是，我们发现，表面活性剂的添加提供了一个协同效应与醇类抑制SARS-CoV-2病毒。本研究提供了一种简单而有效的解决方案，以提高常用消毒剂的杀病毒效率。
Our surrounding environment, especially often-touched contaminated surfaces, plays an important role in the transmission of pathogens in society. The shortage of effective sanitizing fluids, however, became a global challenge quickly after the coronavirus disease-19 (COVID-19) outbreak in December 2019. In this study, we present the effect of surfactants on coronavirus (SARS-CoV-2) viricidal efficiency in sanitizing fluids. Sodium dodecylbenzenesulfonate (SDBS), sodium laureth sulfate (SLS), and two commercial dish soap and liquid hand soap were studied with the goal of evaporation rate reduction in sanitizing liquids to maximize surface contact time. Twelve fluids with different recipes composed of ethanol, isopropanol, SDBS, SLS, glycerin, and water of standardized hardness (WSH) were tested for their evaporation time and viricidal efficiency. Evaporation time increased by 17-63% when surfactant agents were added to the liquid. In addition, surfactant incorporation enhanced the viricidal efficiency between 15 and 27% according to the 4-field test in the EN 16615:2015 European Standard method. Most importantly, however, we found that surfactant addition provides a synergistic effect with alcohols to inactivate the SARS-CoV-2 virus. This study provides a simple, yet effective solution to improve the virucidal efficiency of commonly used sanitizers.