Regulation of immune cell function and differentiation by the NKG2D receptor.
Regulation of immune cell function and differentiation by the NKG2D receptor.
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DOI：
10.1007/s00018-011-0797-0
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发表时间：
2011-11
影响因子：
8
通讯作者：
Polic, Bojan
中科院分区：
文献类型：
--
作者：
Zafirova, Biljana;Wensveen, Felix M.;Gulin, Maja;Polic, Bojan
NKG2D是过去十年中研究最深入的免疫受体之一。其独特的结合和信号传导特性、表达模式和功能由于其有效的抗病毒和抗肿瘤特性而引起了该领域的广泛兴趣。作为活化受体，NKG2D在先天性和适应性免疫系统的细胞上表达。它识别应激诱导的MHC I类配体，并作为病毒感染或DNA损伤危害细胞的分子传感器。虽然NKG2D的激活功能已得到充分证明，但最近对NKG2D缺陷小鼠的分析表明，该受体可能在NK细胞发育过程中起调节作用。在这篇综述中，我们将重新审视NKG2D功能的已知方面，并提出新的见解，提出这种分子对造血分化的影响。
NKG2D is one of the most intensively studied immune receptors of the past decade. Its unique binding and signaling properties, expression pattern, and functions have been attracting much interest within the field due to its potent antiviral and anti-tumor properties. As an activating receptor, NKG2D is expressed on cells of the innate and adaptive immune system. It recognizes stress-induced MHC class I-like ligands and acts as a molecular sensor for cells jeopardized by viral infections or DNA damage. Although the activating functions of NKG2D have been well documented, recent analysis of NKG2D-deficient mice suggests that this receptor may have a regulatory role during NK cell development. In this review, we will revisit known aspects of NKG2D functions and present new insights in the proposed influence of this molecule on hematopoietic differentiation.
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影响因子：
64.8
作者：
Bartkova, J;Horejsi, Z;Bartek, J
通讯作者：
Bartek, J
影响因子：
29.4
作者：
Allez, Matthieu;Tieng, Vannary;Toubert, Antoine
通讯作者：
Toubert, Antoine
影响因子：
11.2
作者：
Ashiru O;Boutet P;Fernández-Messina L;Agüera-González S;Skepper JN;Valés-Gómez M;Reyburn HT
通讯作者：
Reyburn HT
DOI：
10.1084/jem.20081648
发表时间：
2009-04-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dai Z;Turtle CJ;Booth GC;Riddell SR;Gooley TA;Stevens AM;Spies T;Groh V
通讯作者：
Groh V
影响因子：
64.5
作者：
Dai, Chengkai;Whitesell, Luke;Lindquist, Susan
通讯作者：
Lindquist, Susan