The symptoms of autonomic dysfunction in HIV-positive Africans
The symptoms of autonomic dysfunction in HIV-positive Africans
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DOI：
10.1007/s10286-007-0451-y
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发表时间：
2008-02-01
影响因子：
5.8
通讯作者：
D'Elia, Ruggiero
中科院分区：
文献类型：
--
作者：
Compostella, Caterina;Compostella, Leonida;D'Elia, Ruggiero
Human immunodeficiency virus (HIV) infection is associated with autonomic neuropathy. The resultant autonomic dysfunction impairs quality of life and can have fatal consequences. Our aim was to clearly define the symptoms of autonomic dysfunction in African HIV-positive patients and determine whether these symptoms were related with (a) autonomic reflex responses (b) the degree of immunosupression.Thirty-one HIV-positive treatment-naive African patients (mean CD4 cell count 269.5 +/- 253.4/mm(3)) and 12 healthy controls completed a detailed questionnaire (Autonomic System Profile, Mayo Clinic, Rochester, MN) relating to specific symptoms of autonomic dysfunction. After completion of the questionnaire, subjects underwent a standard battery of autonomic reflex tests.The autonomic symptom score was higher in the male HIV-positive patients (26.7 +/- 14.7 points) and female patients with CD4 < 200/mm(3) (24.7 +/- 18.0) than sex-matched controls (male controls, 9.9 +/- 6.8, P < 0.05; female controls, 8.8 +/- 10.1; P < 0.05). Six patients had scores indicative of severe autonomic dysfunction (> 43.8 points). The most common autonomic symptoms were: orthostatic intolerance, secretomotor and gastrointestinal dysfunction. There was no relationship between CD4 cell counts and autonomic symptom scores. The blood pressure response to sustained handgrip was blunted, but all other cardiovascular reflex tests were within the normal range or borderline.African HIV-positive patients report symptoms of autonomic dysfunction, despite normal or borderline autonomic reflex responses.
