Inhibition of tumor growth in a glioma model treated with boron neutron capture therapy.
Inhibition of tumor growth in a glioma model treated with boron neutron capture therapy.
复制标题
用硼中子捕获疗法治疗的神经胶质瘤模型中肿瘤生长的抑制。
DOI：
10.1097/00006123-199009000-00007
复制
发表时间：
1990
期刊：
影响因子：
4.8
通讯作者：
R. Fairchild
中科院分区：
文献类型：
--
作者：
J. Goodman;J. McGregor;N. Clendenon;R. Gahbauer;R. Barth;A. Soloway;R. Fairchild
本研究试图确定F98胶质瘤模型接受硼中子俘获疗法（BNCT）治疗后存活时间的增加是否是由于辐射诱导的内皮细胞和正常组织成分改变抑制肿瘤生长的结果。这种辐射的间接效应被称为肿瘤床效应。采用标准化的BNCT方案，在4 × 10(12) n/cm2的中子辐照前14至17小时静脉注射50 mg/kg的Na2B12H11SH，对一系列荷瘤大鼠进行了研究。10只大鼠作为对照，在肿瘤植入前和植入后均不接受任何治疗。第二组10只大鼠在肿瘤植入前4天给予BNCT治疗；这些动物没有接受进一步的治疗。其余10只大鼠不作预处理，于植入后第10天给予BNCT治疗。植入后17 d，每组2只进行组织学和超微结构分析。未处理的对照动物的生存时间（平均25.8天）与预处理组大鼠的生存时间（平均25.5天）无统计学差异。植入后经BNCT处理的大鼠存活时间明显长于对照组和辐照前大鼠（P < 0.02，平均33.2天）。根据死亡时的测量计算的肿瘤大小指数在所有组中相似。这些结果表明，在该肿瘤模型中，BNCT不会在脑组织中引起肿瘤床效应。BNCT观察到的治疗效果来自于对肿瘤细胞或肿瘤周围新生血管的直接作用。
This investigation attempts to determine whether increased survival time seen when the F98 glioma model is treated with boron neutron capture therapy (BNCT) is a result of inhibition of tumor growth caused by radiation-induced alterations in endothelial cells and normal tissue components. This indirect effect of radiation has been called the tumor bed effect. A series of tumor-bearing rats was studied, using a standardized investigational BNCT protocol consisting of 50 mg/kg of Na2B12H11SH injected intravenously 14 to 17 hours before neutron irradiation at 4 x 10(12) n/cm2. Ten rats, serving as controls, received no treatment either before or after tumor implantation. A second group of 10 rats was treated with BNCT 4 days before tumor implantation; these animals received no further treatment. The remaining group of 10 rats received no pretreatment but was treated with BNCT 10 days after implantation. Histological and ultrastructural analyses were performed in 2 animals from each group 17 days after implantation. Survival times of the untreated control animals (mean, 25.8 days) did not differ statistically from the survival times of the rats in the pretreated group (mean, 25.5 days). The rats treated with BNCT after implantation survived significantly longer (P less than 0.02; mean, 33.2 days) than the controls and the preirradiated animals. Tumor size indices calculated from measurements taken at the time of death were similar in all groups. These results indicate that, with this tumor model, BNCT does not cause a tumor bed effect in cerebral tissue. The therapeutic gains observed with BNCT result from direct effects on tumor cells or on the peritumoral neovascularity.