UTEROTONIC EFFECT OF EVODIA-RUTAECARPA ALKALOIDS
UTEROTONIC EFFECT OF EVODIA-RUTAECARPA ALKALOIDS
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DOI：
10.1021/np50011a008
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发表时间：
1980-01-01
影响因子：
5.1
通讯作者：
SANKAWA, U
中科院分区：
文献类型：
--
作者：
KING, CL;KONG, YC;SANKAWA, U
从芦竹未熟果实中分离得到芦竹松素和脱氢演化二胺。体外大鼠子宫扩张实验显示两种生物碱均有活性。在以大鼠为动物模型的体内子宫扩张实验中，脱氢乙二胺有活性。在给药剂量下，参比盐酸乙伏二胺没有子宫扩张活性。
Rutaecarpine and dehydroevodiamine were isolated from the unripe fruit of E. rutaecarpa. In vitro uterotonic assay on rat uterus showed both alkaloids to be active. In the in vivo uterotonic assay using rats as the animal model dehydroevodiamine was active. Reference evodiamine hydrochloride was devoid of uterontonic activity at the doses administered.