Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment.
Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment.
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DOI：
10.31491/apt.2020.12.046
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发表时间：
2020-12-31
期刊：
影响因子：
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通讯作者：
Zhu L
中科院分区：
文献类型：
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作者：
Nickel K;Bjorner M;Ladiges W;Zhu L
通过对接受非致死剂量环磷酰胺（环磷酰胺）的不同年龄的C57 BL/6小鼠的白色血细胞计数来测量对压力的反应能力（定义为恢复力）。中性粒细胞计数下降，然后以一致和年龄依赖的方式反弹。低中性粒细胞反弹与中年小鼠学习能力的改善相关，表明CYP诱导的中性粒细胞反应可能预测对衰老的恢复力。
The ability to respond to stress, defined as resilience, was measured by white blood cell counts in C57BL/6 mice of various ages receiving a nonlethal dose of cyclophosphamide (CYP). Neutrophil counts dipped and then rebounded in a consistent and age-dependent manner. Low neutrophil rebound correlated with improved learning in middle-age mice suggesting CYP-nduced neutrophil response may predict resilience to aging.