Human papillomavirus 16 E6, L1, L2 and E2 gene variants in cervical lesion progression
Human papillomavirus 16 E6, L1, L2 and E2 gene variants in cervical lesion progression
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DOI：
10.1016/j.virusres.2007.08.003
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发表时间：
2008-01-01
期刊：
影响因子：
5
通讯作者：
Zehbe, I.
中科院分区：
文献类型：
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作者：
Lee, K.;Magalhaes, I.;Zehbe, I.
人类乳头瘤病毒（HPV） 16e6基因组变异350G在持续感染和宫颈疾病进展的女性中比hpv16e6原型350T更普遍。在这项研究中，我们检查了进展到高度病变但感染了原型350T的女性是否表现出其他HPV基因（如L1， L2和E2）的变异。虽然我们在这些基因中发现了变异，但它们无法解释这种现象。事实上，它们与350G型和350T原型相似。这些数据表明，在决定宫颈病变进展的风险中，HPV 16e6基因的多态性而不是其他分析基因的多态性发挥了作用，并且可能还需要其他因素。(c) 2007 Elsevier B.V.版权所有
The human papillomavirus (HPV) 16 E6 genome variant 350G has been found to be more prevalent in women with persistent infection and cervical disease progression than the HPV16 E6 prototype 350T. In this study, we examined whether women who progressed to a high-grade lesion, yet were infected with the prototype 350T, showed variants in other HPV genes such as L1, L2 and E2. Although we detected variants within these genes, they could not explain this phenomenon. Indeed they correlated similarly with variant 350G and prototype 350T. These data indicate that polymorphisms in HPV 16 E6 rather than in the other analyzed genes play a role in determining the risk for cervical lesion progression and that additional factors are likely to be required as well. (c) 2007 Elsevier B.V. All rights reserved.