Mitochondrial biogenesis: which part of "NO" do we understand?
Mitochondrial biogenesis: which part of "NO" do we understand?
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DOI：
10.1002/bies.10298
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发表时间：
2003-06-01
期刊：
影响因子：
4
通讯作者：
Shoubridge, EA
中科院分区：
文献类型：
--
作者：
Leary, SC;Shoubridge, EA
A recent paper by Nisoli et al.((1)) provides the first evidence that elevated levels of nitric oxide (NO) stimulate mitochondrial biogenesis in a number of cell lines via a soluble guanylate-cyclase-dependent signaling pathway that activates PGC1alpha(peroxisome proliferator-activated receptor gamma coactivator-1alpha), a master regulator of mitochondrial content. These results raise intriguing possibilities for a role of NO in modulating mitochondrial content in response to physiological stimuli such as exercise or cold exposure. However, whether this signaling cascade represents a widespread mechanism by which mammalian tissues regulate mitochondrial content, and how it might integrate with other pathways that control PGC1alpha expression, remain unclear. BioEssays25:538-541,2003. (C) 2003 Wiley Periodicals, Inc.
