Improvement of kidney transplant regraft results by using trauma death donors.
Improvement of kidney transplant regraft results by using trauma death donors.
复制标题
通过使用创伤死亡供体来改善肾移植再移植的结果。
DOI：
10.1097/00007890-198712000-00014
复制
发表时间：
1987
期刊：
影响因子：
6.2
通讯作者：
Terasaki,PI
中科院分区：
文献类型：
--
作者：
Cecka,JM;Terasaki,PI
Patients who have lost a transplanted kidney are widely recognized as high-risk patients for retransplantation. We have found a profound difference in cadaver kidney regraft survival associated with the age and sex of the donor. Kidneys from male cadaver donors yielded significantly higher graft survival rates than kidneys from female donors. The difference in graft survival at one year was 7% for all first transplants (n= 2974), 14% if the recipient was sensitized, and 18% in 688 patients being regrafted. The difference was even more striking in regraft recipients of kidneys from young male donors (72% one-year graft survival) as compared with recipients of kidneys from older female donors (44% one-year graft survival). The donor age and sex effects correlated well with the cause of donor death. Young male donors accounted for 59% of trauma deaths whereas older female donors made up only 7%. Nontrauma donors, on the other hand, were 38% older female and 14% younger male. The survival of trauma-death donor kidneys in regrafted patients was 69% at one year and 37% for nontrauma donor kidneys, a 32% difference (P< 0.001). These results indicate that regraft survival could be significantly increased through the use of cadaver kidneys from trauma death donors.
