Adrenal Function and Alcoholism: II. Catecholamines
Adrenal Function and Alcoholism: II. Catecholamines
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肾上腺功能和酗酒：II。
作者：
J. Mendelson;M. Ogata;N. Mello
患者;测定慢性酒精摄入期间和戒酒后饮酒者尿中儿茶酚胺及其代谢物的排泄量。血液中酒精浓度的大小与肾上腺素、甲肾上腺素、去甲肾上腺素和去甲肾上腺素的分泌增加之间存在剂量反应关系。肾上腺素的最大排泄发生在受试者停止饮酒后出现戒断体征和症状时。当受试者饮酒时，VMA排泄显著减少，同时MHPG排泄增加。这些数据表明，慢性乙醇摄入与肾上腺素能活性的刺激和儿茶酚胺分解代谢途径的改变有关。
&NA; Urinary excretion of catecholamines and their metabolites were determined in alcoholic subjects during chronic ethanol ingestion and after alcohol withdrawal. A dose response relationship was found between magnitude of blood alcohol levels and increased excretion of epinephrine, metanephrine, norepinephrine and noremetanephrine. Maximal excretion of epinephrine occurred when subjects developed withdrawal signs and symptoms after they had stopped drinking. A significant decrease in excretion of VMA and a concomitant increase in MHPG excretion occurred when subjects were drinking. These data indicate that chronic ethanol ingestion is associated with both stimulation of adrenergic activity and alteration in pathways of catecholamine catabolism.