Digit ratio (2D:4D) and behavioral differences between inbred mouse strains
Digit ratio (2D:4D) and behavioral differences between inbred mouse strains
复制标题
DOI：
10.1111/j.1601-183x.2004.00110.x
复制
发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Hurd, PL
中科院分区：
文献类型：
--
作者：
Bailey, AA;Wahlsten, D;Hurd, PL
足趾比（2D：4D）是一种性状，在许多物种中存在性别差异。在人类中，男性的第二手指（2Ds）（食指）通常比第四手指（4Ds）（无名指）短，而女性的手指长度更相等。较小的、更男性化的手指比例被认为与更高的产前睾酮水平、对产前雄激素更敏感或两者兼而有之有关。手指比例更男性化的男性在运动中表现出更强的能力、成就和速度，并且倾向于报告他们更具身体攻击性。先前的研究表明，实验室小鼠的后爪与人类的手具有相同的性分化模式，雄性小鼠的2D：4D低于雌性小鼠。对8个近交系小鼠的后爪趾比进行了测量。这些测量是在对应变、性别和爪是来自左侧还是右侧不知情的情况下进行的。我们发现品系之间的指数比差异很大，这表明近交系小鼠是一个很有前途的系统，用于调查指数比和行为性状之间的相关性。
Digit ratio (2D:4D) is a trait, which is sexually differentiated in a variety of species. In humans, males typically have shorter second digits (2Ds) (index fingers) compared to fourth digits (4Ds) (ring fingers) whereas females' fingers are more equal in length. Smaller, more masculine, digit ratios are thought to be associated with higher prenatal testosterone levels, greater sensitivity to prenatal androgens or both. Men with more masculine digit ratios have shown increased ability, achievement and speed in sports and tend to report that they are more physically aggressive. Previous research has shown the same sexually differentiated pattern in the hind paws of laboratory mice as in human hands, males have lower 2D:4D than females. We measured hind paw digit ratio in mice of eight inbred strains. These measurements were made while blind to strain, sex and whether the paw was from the left or right side. We found large differences in digit ratio between the strains and suggest that inbred mice are a promising system for investigating the correlation between digit ratio and behavioral traits.