Iron Loading and Overloading due to Ineffective Erythropoiesis.
Iron Loading and Overloading due to Ineffective Erythropoiesis.
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DOI：
10.1155/2010/358283
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发表时间：
2010
影响因子：
--
通讯作者：
Miller JL
中科院分区：
文献类型：
--
作者：
Tanno T;Miller JL
红细胞生成描述了导致成熟循环红细胞产生的细胞增殖和分化的造血过程。成年人每天产生2000亿个红细胞，每个红细胞中含有大约10亿个铁分子。因此，用于血红蛋白产生的铁使用是血浆铁供应和需求的主要调节剂。在许多贫血症中，需要来自饮食和组织储存的额外铁来源来满足红细胞需求。在由无效红细胞生成引起的贫血的子集中，即使在没有输血的情况下，组织中的铁吸收和积累也增加到超过红细胞生成需求的水平。由于无效的红细胞生成导致铁超载的机制尚未完全了解。基于目前可用的数据，它是在这篇评论中提出，负载和超载的铁可以调节不同的或组合机制与红细胞生成。铁的红系调节的概念被拓宽到包括在无效红细胞生成的情况下的生理和病理铁调素抑制。
Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron molecules are incorporated into the hemoglobin contained within each erythrocyte. Thus, iron usage for the hemoglobin production is a primary regulator of plasma iron supply and demand. In many anemias, additional sources of iron from diet and tissue stores are needed to meet the erythroid demand. Among a subset of anemias that arise from ineffective erythropoiesis, iron absorption and accumulation in the tissues increases to levels that are in excess of erythropoiesis demand even in the absence of transfusion. The mechanisms responsible for iron overloading due to ineffective erythropoiesis are not fully understood. Based upon data that is currently available, it is proposed in this review that loading and overloading of iron can be regulated by distinct or combined mechanisms associated with erythropoiesis. The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis.