Activation of mast cells in skin abscess induced by Staphylococcus aureus (S. aureus) infection in mice
Activation of mast cells in skin abscess induced by Staphylococcus aureus (S. aureus) infection in mice
复制标题
小鼠金黄色葡萄球菌（S. aureus）感染引起的皮肤脓肿中肥大细胞的激活。
DOI：
10.1016/j.rvsc.2018.01.016
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发表时间：
2018-06-01
影响因子：
2.4
通讯作者：
Wang, Decheng
中科院分区：
文献类型：
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作者：
Lei, Zhiqiang;Zhang, Ding;Wang, Decheng
皮肤脓肿是一种常见的炎症性疾病，发生在普遍存在的S。金黄色葡萄球菌感染。在我们的研究中，皮肤脓肿小鼠模型的建立和肥大细胞趋化动力学进行了评估。在S.金黄色葡萄球菌感染的小鼠，在真皮中观察到严重的炎性细胞浸润，并且肥大细胞在皮肤中显著积聚。肥大细胞活化标志物类胰蛋白酶与肥大细胞活性呈正相关。组织中鉴定的肥大细胞可能被激活，因为它们与细胞脱粒和类胰蛋白酶的存在相关。结果提示肥大细胞及其介导的类胰蛋白酶参与了链球菌引起的皮肤脓肿炎症反应。金黄色葡萄球菌感染。
The skin abscess is a common inflammatory disease that occurs following the ubiquitous S. aureus infection. In our study, a skin abscess murine model was established and the dynamics of mast cells chemotaxing was evaluated. In the S. aureus-infected mice, severe infiltration of inflammatory cells in the dermis were observed, and mast cells were markedly accumulated in the skins. Besides, tryptase, the marker for mast cells activation, has a positive correlation with mast cell activity. The mast cells identified in the tissues were likely to be activated since they were associated with cell degranulation and the presence of tryptase. Our results suggested that mast cells and its mediator tryptase contribute to the inflammation of skin abscess induced by S. aureus infection.