DIFFERENTIAL IMPAIRMENT OF SEMANTIC AND EPISODIC MEMORY IN ALZHEIMERS AND HUNTINGTONS DISEASES - A CONTROLLED PROSPECTIVE-STUDY
DIFFERENTIAL IMPAIRMENT OF SEMANTIC AND EPISODIC MEMORY IN ALZHEIMERS AND HUNTINGTONS DISEASES - A CONTROLLED PROSPECTIVE-STUDY
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DOI：
10.1136/jnnp.53.12.1089
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发表时间：
1990-12-01
影响因子：
11
通讯作者：
BUTTERS, N
中科院分区：
文献类型：
--
作者：
HODGES, JR;SALMON, DP;BUTTERS, N
一项前瞻性对照研究比较了14名阿尔茨海默型痴呆症（DAT）患者和14名亨廷顿病（HD）患者在一系列语义和情景记忆测试中的表现，这些患者的痴呆症总体水平相匹配。DAT患者在延迟言语和图形情景记忆的测量上明显受损，此外，在依赖于语义知识（命名，数字信息，相似性和类别流畅性）的完整性的测试中表现出更快的下降速度。相比之下，HD患者的情况明显更糟，并且在字母流畅性测试中表现出更快的下降，这是一项对检索缺陷特别敏感的任务。HD组在词汇测试和几何图形抄写方面的成绩也明显低于DAT组。观察到的双重分离提供了令人信服的证据，病因学上不同形式的痴呆症导致不同模式的认知障碍。
A controlled prospective study compared the performance of 14 patients with dementia of Alzheimer type (DAT) and 14 patients with Huntington's Disease (HD), who were matched for overall level of dementia, on a battery of semantic and episodic memory tests. The DAT patients were significantly more impaired on measures of delayed verbal and figural episodic memory, and in addition showed a more rapid rate of decline on tests which depend upon the integrity of semantic knowledge (naming, number information, similarities and category fluency). In contrast, the HD patients were significantly worse, and showed a more rapid decline on the letter fluency test, a task especially sensitive to deficiencies in retrieval. The HD patients were also more impaired than DAT patients on vocabulary test and on copying geometric figures. The observed double dissociations offer compelling evidence that aetiologically distinct forms of dementing illness result in different patterns of cognitive impairment.