MAXIMUM LENGTH FOR CONTRACTION IN VERTEBRATE STRIATED MUSCLE
MAXIMUM LENGTH FOR CONTRACTION IN VERTEBRATE STRIATED MUSCLE
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DOI：
10.1113/jphysiol.1961.sp006665
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发表时间：
1961-01-01
影响因子：
5.5
通讯作者：
PEACHEY, LD
中科院分区：
文献类型：
--
作者：
HUXLEY, AF;PEACHEY, LD
在孤立的横纹肌纤维的青蛙拉伸下的条纹间距是大大低于其长度的主要部分的两端附近。在等长强直过程中，被拉伸的纤维的张力上升缓慢，这是由于纤维末端的缩短。在等渗性破伤风中，通过电影显微照相术发现，在条纹间距超过接近3.5 [mu]的临界值的点处没有发生缩短。在同一肌肉中的细丝长度通过电子显微镜在切片和分离的肌原纤维上测定。如果肌节长度超过3.5 [mu]，则两组肌丝不重叠。因此，如果纤维被拉伸到两组长丝之间没有重叠的程度，收缩就停止发生。这被认为是证据，即收缩取决于两种类型的细丝在它们重叠的区域中的相互作用，正如基于细丝的相对滑动运动发生长度变化的想法的各种收缩理论所假设的那样。
In isolated striated muscle fibers of the frog under stretch the striation spacing was substantially lower near the ends than in the main part of their length. The slow tension rise during an isometric tetanus of greatly stretched fibers was found to be due to shortening of the ends. In isotonic tetani it was found by cine-micrography that no shortening occurs at points where the striation spacing exceeds a critical value which is close to 3.5 [mu]. The filament lengths in the same muscle were determined by electron microscopy both on sections and on separated myofibrils. The two sets of filaments do not overlap if the sarcomere length exceeds 3.5 [mu]. Contraction thus ceases to occur if a fiber is stretched to such an extent that there is no overlap between the two sets of filaments. This is taken as evidence, that contraction depends on an interaction between filaments of the 2 types in the regions where they overlap, as postulated in the various theories of contraction based on the idea that length changes take place by a relative sliding motion of the filaments.