Sirtuin 6: A potential therapeutic target for cardiovascular diseases
Sirtuin 6: A potential therapeutic target for cardiovascular diseases
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Sirtuin 6：心血管疾病的潜在治疗靶点
DOI：
10.1016/j.phrs.2020.105214
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发表时间：
2021-01-17
影响因子：
9.3
通讯作者：
Tang Qizhu
中科院分区：
文献类型：
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作者：
Xie Saiyang;Deng Wei;Tang Qizhu
心血管疾病（Cardiovascular Diseases，CVD）是一种严重危害人类健康的疾病，其发病率和死亡率在全球范围内都很高，许多信号分子参与了这一病理过程。Sirtuin 6（SIRT6）是NAD（+）依赖性去乙酰化酶家族的一员，在调节生物体内平衡、长寿和多种疾病中发挥着重要作用。更重要的是，SIRT6在葡萄糖和脂质代谢、炎症和基因组稳定性方面发挥着不可或缺的作用，从而导致各种CVD的发生和发展。最新进展：在sirtuins中，SIRT6由于其对心力衰竭、心血管重塑和动脉粥样硬化的保护作用而频繁被发现，并被确定为心血管疾病的重要干预靶点，使SIRT6成为临床关注的焦点。在此，我们提供了SIRT6调节CVD的当前分子机制的概述，并强调了CVD的潜在治疗靶点。
Cardiovascular diseases (CVDs) are serious diseases endangering human health due to high morbidity and mortality worldwide, and numerous signal molecules are involved in this pathological process. As a member of the Sirtuin family NAD(+)-dependent deacetylases, indeed, Sirtuin 6 (SIRT6) plays an important role in regulating biological homeostasis, longevity, and various diseases. More importantly, SIRT6 performs as an indispensable role in glucose and lipid metabolism, inflammation and genomic stability for the occurrence and development of various CVDs. Recent advances: among sirtuins, SIRT6 was frequently unveiled thanks for its protective roles against heart failure, cardiovascular remodeling and atherosclerosis, and identified as an essential intervention target of CVDs, bringing SIRT6 into the focus of clinical interest. Herein, we provide an overview of the current molecular mechanism through which SIRT6 regulates CVDs, and we highlight a potential therapeutic target for CVDs.