Hepatic flow parameters measured with MR imaging and Doppler US: Correlations with degree of cirrhosis and portal hypertension
Hepatic flow parameters measured with MR imaging and Doppler US: Correlations with degree of cirrhosis and portal hypertension
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DOI：
10.1148/radiol.2292021128
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发表时间：
2003-11-01
期刊：
影响因子：
19.7
通讯作者：
Van Beers, BE
中科院分区：
文献类型：
--
作者：
Annet, L;Materne, R;Van Beers, BE
目的：探讨磁共振（MR）和多普勒超声（US）测量的肝血流动力学参数与肝硬化和门静脉高压症严重程度的相关性。材料与方法：本研究纳入46例门静脉压测量患者（3例肝脏正常，12例慢性肝炎，31例肝硬化[Child-Pugh A级肝硬化10例，B级肝硬化13例，C级肝硬化8例]）。动态增强磁共振成像测量肝表观灌注、动脉和门静脉表观灌注门静脉分数分布、体积和平均传递时间。多普勒超声测量门静脉速度、门静脉流量、充血指数、右肝动脉阻力指数、改良肝指数。肝硬化患者和无肝硬化患者的结果用Wilcoxon秩和检验进行比较。用Spearman秩相关系数评价相关性。结果：肝硬化患者与无肝硬化患者MR成像除血流分布体积外，其他血流参数差异均有统计学意义（P < 0.05）。磁共振成像测量的所有流量参数与门静脉压力有显著相关性（P < 0.02）。表观动脉（P = 0.024）和门脉（P < 0.001）灌注、门脉分数（P < 0.001）灌注、门脉（P < 0.001）和平均传递时间（P = 0.004）与Child-Pugh分级相关。多普勒超声测量的血流参数在肝硬化患者和无肝硬化患者之间无显著差异。只有右肝动脉阻力（P < 0.007）和门静脉流量（P < 0.043）与门静脉压力呈弱相关（r < 0.7）。多普勒超声参数与Child-Pugh分级无相关性。结论：磁共振成像测量的肝血流参数与肝硬化和门静脉高压症的严重程度相关。多普勒超声参数与门静脉压力相关性较弱。(c) rsna, 2003。
PURPOSE: To determine the correlations between hemodynamic parameters of hepatic flow measured with magnetic resonance (MR) imaging and Doppler ultrasonography (US) and the severity of cirrhosis and portal hypertension.MATERIALS AND METHODS: Forty-six patients referred for measurements of portal venous pressure (three with normal liver, 12 with chronic hepatitis, and 31 with cirrhosis [10 with Child-Pugh class A cirrhosis; 13 with class B cirrhosis; and eight with class C cirrhosis]) were included in the study. Apparent liver perfusion, apparent arterial and portal perfusion portal fraction distribution volume and mean transit time were measured with dynamic contrast material-enhanced MR imaging. Portal velocity, portal flow, congestion index, right hepatic artery resistance index, and modified hepatic index were measured with Doppler US. Results in patients with cirrhosis and those without cirrhosis were compared with the Wilcoxon rank sum test. Correlations were assessed with Spearman rank correlation coefficients.RESULTS: With MR imaging, all flow parameters except distribution volume were significantly different between patients with and those without cirrhosis (P < .05). There was a significant correlation between all flow parameters measured with MR imaging and portal pressure (P < .02). Apparent arterial (P = .024) and portal (P < .001) perfusion, portal fraction) perfusion, portal (P < .001), and mean transit time (P = .004) were correlated with Child-Pugh class. Flow parameters measured with Doppler US did not differ significantly between patients with and those without cirrhosis. Only right hepatic arterial resistance (P < .007) and portal flow (P < .043) were weakly (r < 0.7) correlated with portal pressure. No Doppler US parameter was correlated with Child-Pugh class.CONCLUSION: Hepatic flow parameters measured with MR imaging correlate with the severity of cirrhosis and portal hypertension. Doppler US parameters are only weakly correlated with portal pressure. (C) RSNA, 2003.