Sensitivity of flow patterns in aneurysms on the anterior communicating artery to anatomic variations of the cerebral arterial network
Sensitivity of flow patterns in aneurysms on the anterior communicating artery to anatomic variations of the cerebral arterial network
复制标题
前交通动脉瘤血流模式对脑动脉网络解剖变化的敏感性
DOI：
10.1016/j.jbiomech.2016.09.031
复制
发表时间：
2016-11-07
影响因子：
2.4
通讯作者：
Liu, Hao
中科院分区：
文献类型：
--
作者：
Liang, Fuyou;Liu, Xiaosheng;Liu, Hao
最近的研究提出了越来越多的关注的可靠性的计算机模型在再现体内脑动脉瘤的血流动力学。边界条件问题是最经常解决的问题之一，因为三维（3-D）建模通常限于局部动脉段。本研究的重点是前交通动脉（ACoA）上的动脉瘤，其代表了检测到的脑动脉瘤的一个大亚组，特别是与位于其他区域的动脉瘤相比，其破裂风险相对较高。使用三维血流动力学模型研究了三个前交通动脉瘤中血流对边界条件的敏感性。三维模型的边界条件由脑动脉网络的一维（1-D）模型预测。1-D模型的参数分别基于从医学图像导出的群体平均数据和患者特异性数据来分配，从而产生群体通用模型和患者特异性模型。此外，粒子图像测速（PIV）实验进行验证的代码用于模拟颅内血流。结果表明，将动脉瘤模型的边界条件从人群通用边界条件切换到患者特定边界条件后，动脉瘤内的涡流结构、撞击区域、壁面剪切应力和振荡剪切指数的大小和空间分布等均发生了显著变化。特别是，血液动力学量的方式和程度的影响，边界条件表现出显着的患者间的变异性。总之，我们的研究强调了在以ACoA动脉瘤为重点的模型研究中对边界条件进行患者特定治疗的重要性。(C)2016爱思唯尔有限公司版权所有。
Recent studies raised increasing concern about the reliability of computer models in reproducing in vivo hemodynamics in cerebral aneurysms. Boundary condition problem is among the most frequently addressed issues since three-dimensional (3-D) modeling is usually restricted to local arterial segments. The present study focused on aneurysms on the anterior communicating artery (ACoA) which represent a large subgroup of detected cerebral aneurysms and, in particular, have a relatively high risk of rupture compared to aneurysms located in other regions. The sensitivity of blood flows in three ACoA aneurysms to boundary conditions was investigated using 3-D hemodynamic models. The boundary conditions of the 3-D models were predicted by a one-dimensional (1-D) model of the cerebral arterial network. The parameters of the 1-D model were assigned based respectively on population-averaged data and patient specific data derived from medical images, yielding a population-generic model and a patient-specific model. In addition, particle image velocimetry (PIV) experiments were performed to validate the code used to simulate intra-aneurysmal blood flows. Obtained results showed that switching the boundary conditions of the aneurysm models from population-generic ones to patient-specific ones led to pronounced changes in simulated intra-aneurysmal flow patterns in terms of vortex structure, impingement region and the magnitude and spatial distribution of wall shear stress and oscillatory shear index. In particular, the way and the degree in which hemodynamic quantities are influenced by boundary conditions exhibited pronounced inter-patient variability. In summary, our study underlines the importance of patient-specific treatment of boundary conditions in model studies focusing on ACoA aneurysms. (C) 2016 Elsevier Ltd. All rights reserved.