Distribution of human single‐nucleotide polymorphisms is approximated by the power law and represents a fractal structure
Distribution of human single‐nucleotide polymorphisms is approximated by the power law and represents a fractal structure
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人类单核苷酸多态性的分布由幂律近似并表示分形结构
DOI：
10.1111/gtc.12344
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发表时间：
2016
期刊：
影响因子：
2.1
通讯作者：
M. Furusawa
中科院分区：
文献类型：
--
作者：
N. Gouda;Yuh Shiwa;Motohiro Akashi;H. Yoshikawa;Ken Kasahara;M. Furusawa
单核苷酸多态性（SNP）是进化的主要原因之一。分析了在全基因组范围内详细检查的人类SNP的分布。三个离散的人类SNP数据库用于该分析，并且从这些数据库获得相似的结果。发现SNP之间的距离的分布近似于幂律，并且包含SNP的区域的形状具有所谓的分形结构。虽然SNP的分布服从这样一个物理定律的原因尚不清楚，但人们试图推测具有分形结构的人类染色质的三维结构。
Single‐nucleotide polymorphisms (SNPs) are one of the main causes of evolution. The distribution of human SNPs, which were examined in detail genomewide, was analyzed. Three discrete databases of human SNPs were used for this analysis, and similar results were obtained from these databases. It was found that the distribution of the distance between SNPs was approximated by the power law, and the shape of the regions including SNPs had the so‐called fractal structure. Although the reason why the distribution of SNPs obeys such a certain law of physics is unclear, a speculation was attempted in connection with the three‐dimensional structure of human chromatin which has a fractal structure.
影响因子：
16
作者：
Ciccia A;Elledge SJ
通讯作者：
Elledge SJ