[Time course of changes in gustatory function test results and subjective symptoms, and predictive factors for response in patients with taste disorder receiving 24-week zinc replacement treatment].
[Time course of changes in gustatory function test results and subjective symptoms, and predictive factors for response in patients with taste disorder receiving 24-week zinc replacement treatment].
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接受24周锌替代治疗的味觉障碍患者味觉功能测试结果和主观症状变化的时间过程及反应预测因素
DOI：
10.3950/jibiinkoka.117.1093
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
M. Ikeda
中科院分区：
文献类型：
--
作者：
M. Sakagami;Y. Kurono;A. Inokuchi;N. Takeda;T. Aiba;T. Nin;M. Ikeda
在味觉障碍中，患者的主诉和味觉功能测试结果之间的一致性不一定在最初的医院就诊和治疗过程中都被发现;因此，难以评估治疗反应并基于评估的治疗反应来审查治疗策略。本研究调查了44例味觉障碍患者的椎间盘味觉测量结果和主观症状评分变化的时间过程，这些患者被认为有资格接受锌替代治疗，并接受150 mg/天剂量的Polaprezinc（相当于34 mg/天剂量的锌）长达24周。该研究还根据反应的预测因素（如患者背景和治疗过程中评估的椎间盘味觉测量结果）检查了治疗结局的潜在差异。结果显示，患者的味觉测试结果与主观症状评分呈现不同的时程变化。在治疗第12周，通过圆盘味觉测量法测量的应答率为47.7%，随后在第24周缓慢增加至56.8%。另一方面，主观症状评分显示出与时间成比例的改善，直至第24周。在本研究纳入的患者中，根据治疗第12周时通过椎间盘味觉测定确定的改善趋势的存在或不存在，发现了明显的差异，尽管根据患者背景，最终治疗反应（包括味觉障碍的类别）没有差异。显示改善趋势的患者在最终缓解率和主观症状评分方面的治疗反应明显更好，而未显示改善趋势的患者对随后12周的持续治疗反应的可能性较小。
In a taste disorder, an agreement between patients' complaints and gustatory function test results is not necessarily found both at the initial hospital visit and during the course of treatment; therefore, it is difficult to assess treatment responses and review treatment strategies based on the assessed treatment responses. The present study investigated the time course of changes in disc gustometry results and subjective symptom scores measured at 4-week intervals in 44 patients with a taste disorder who were considered eligible for zinc replacement treatment and who received polaprezinc at a dose of 150 mg/day (equivalent to a 34 mg/day dose of zinc) for up to 24 weeks. The study also examined the potential differences in treatment outcomes according to the predictive factors for response such as patient background and assessed disc gustometry results during the course of treatment. Results indicated that disc gustometry results and subjective symptom scores showed different time courses of changes. The response rate as measured by disc gustometry was 47.7% at week 12 of treatment, and showed a subsequent slow increase to 56.8% at week 24. On the other hand, subjective symptom scores showed a time-proportional improvement up to week 24. Among the patients included in the present study, a clear difference was found according to the presence or absence of an improving trend as determined by disc gustometry at week 12 of treatment, although there were no differences in ultimate treatment responses, including categories of taste disorder, according to patient background. Patients showing a trend toward improvement had significantly better treatment responses in terms of both ultimate response rates and subjective symptom scores, whereas patients showing no trend toward improvement were less likely to respond to the subsequent 12-week continued treatment.