CHRONIC NON-SPECIFIC LUNG-DISEASE AND OCCUPATIONAL EXPOSURES ESTIMATED BY MEANS OF A JOB EXPOSURE MATRIX - THE ZUTPHEN STUDY
CHRONIC NON-SPECIFIC LUNG-DISEASE AND OCCUPATIONAL EXPOSURES ESTIMATED BY MEANS OF A JOB EXPOSURE MATRIX - THE ZUTPHEN STUDY
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DOI：
10.1093/ije/18.2.382
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发表时间：
1989-06-01
影响因子：
7.7
通讯作者：
KROMHOUT, D
中科院分区：
文献类型：
--
作者：
HEEDERIK, D;POUWELS, H;KROMHOUT, D
本研究使用了荷兰对1960年代开始的七国研究的贡献-祖特芬研究所收集的信息。在1985年的调查中，1266名男性中有939人（74%）参加了调查。根据BMRC慢性非特异性肺病（CNSLD）问卷对所有参与者进行了访谈，并由训练有素的医生对CNSLD投诉进行了医学检查。医生还填写了一份调查问卷，其中包括有关哮喘、支气管炎和肺气肿既往治疗的问题。根据最长时间的工作和收益，通过工作暴露矩阵生成暴露，并将其分为12个暴露类别。使用职业暴露作为行业因变量，考虑吸烟习惯、年龄和社会经济地位，进行logistic回归分析。对于医生诊断和治疗肺气肿和/或支气管炎，发现最强的优势比升高，表明职业暴露的不利影响。相比之下，曾接受哮喘治疗的变量的优势比小于1，大多数暴露变量表明存在选择效应。在一项分析中，所有曾经接受过哮喘治疗的人都被排除在外，与第一次分析相比，优势比增加了。工作暴露矩阵和CNSLD产生的职业暴露之间的关系比最近在文献中报道的更强。
Information gathered in the Zutphen Study, the Dutch contribution to the Seven Countries Study that started in the 1960s, was used in this study. Of the 1266 men invited to take part in the 1985 survey, 939 (74%) participated. All participants were interviewed according to the BMRC chronic non-specific lung disease (CNSLD) questionnaire and medically examined for CNSLD complaints by a trained physician. The physician also filled in a questionnaire containing quesions concerning previous treatments for asthma, bronchitis and emphysema. Exposures were generated by means of a job exposure matrix on the basis of the longest performed job and the gain and grouped into 12 exposure categories. A logistic regression analysis was performed using the occupational exposures as the sector of industry dependent variables in allowing for smoking habits, age and socioeconomic status. For the diagnosis by the physician and treatment for emphysema and or bronchitis, the strongest elevated odds ratios were found, indicating an adverse effect of the occupational exposures. In contrast, the variable ever treated for asthma had odds ratios smaller than one with most of the exposure variables indicating a selection effect. In an analysis in which everyone who was ever treated for asthma was excluded an increase in the odds ratios compared with the first analysis was seen. The relationships between occupational exposures as generated by the job exposure matrix and CNSLD were stronger than those recently reported in the literature.