Prevalence and Distribution of Abdominal Aortic Calcium by Gender and Age Group in a Community-Based Cohort (from the Framingham Heart Study)
Prevalence and Distribution of Abdominal Aortic Calcium by Gender and Age Group in a Community-Based Cohort (from the Framingham Heart Study)
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DOI：
10.1016/j.amjcard.2012.05.020
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发表时间：
2012-09-15
影响因子：
2.8
通讯作者：
O'Donnell, Christopher J.
中科院分区：
文献类型：
--
作者：
Chuang, Michael L.;Massaro, Joseph M.;O'Donnell, Christopher J.
腹主动脉钙(AAC)与心血管疾病相关。然而，AAC在没有标准心血管疾病危险因素的社区人群中的年龄和性别相关分布尚未被描述。1998年至2005年，弗雷明翰心脏研究子代和第三代队列中共有3285名参与者(年龄50.2+/-9.9岁)接受了腹部多探测器计算机断层扫描。AAC的存在和数量由有经验的读者使用标准化标准进行量化(Agatston评分)。确定了一个没有高血压、高脂血症、糖尿病、肥胖和吸烟的健康参照组样本(n=1,656,803名男性)，并按性别和年龄(=75岁)对参与者进行了分层。AAC的患病率和负担在两个年龄组中都随着年龄的增长而单调和超早期地增加，但在各个年龄组中男性比女性更大。对于那些0 AAC。在整个研究样本中，AAC患病率和负担随着年龄的增加而类似地增加。将参照组AAC的第90个百分位数定义为“高”，在整个研究样本中，高AAC的患病率为每一性别19%。在整个研究样本中，AAC还增加了使用Framingham风险评分计算的10年冠心病风险类别。我们发现AAC在白人、自由生活的成人队列中广泛流行，AAC的负担与10年的冠状动脉风险相关。由Elsevier Inc.出版(Am J Medicol 2012；110：891-896)
Abdominal aortic calcium (AAC) is associated with incident cardiovascular disease. However, the age- and gender-related distribution of AAC in a community-dwelling population free of standard cardiovascular disease risk factors has not been described. A total of 3,285 participants (aged 50.2 +/- 9.9 years) in the Framingham Heart Study Offspring and Third Generation cohorts underwent abdominal multidetector computed tomography from 1998 to 2005. The presence and amount of AAC was quantified (Agatston score) by an experienced reader using standardized criteria. A healthy referent subsample (n = 1,656, 803 men) free of hypertension, hyperlipidemia, diabetes, obesity, and smoking was identified, and participants were stratified by gender and age (= 75 years). The prevalence and burden of AAC increased monotonically and supralinearly with age in both genders but was greater in men than in women in each age group. For those 0 AAC. Across the entire study sample, AAC prevalence and burden similarly increased with greater age. Defining the 90th percentile of the referent group AAC as "high," the prevalence of high AAC was 19% for each gender in the overall study sample. The AAC also increased across categories of 10-year coronary heart disease risk, as calculated using the Framingham Risk Score, in the entire study sample. We found AAC to be widely prevalent, with the burden of AAC associated with 10-year coronary risk, in a white, free-living adult cohort. Published by Elsevier Inc. (Am J Cardiol 2012;110:891-896)