Initiation of spontaneous epileptiform activity in the neocortical slice.
Initiation of spontaneous epileptiform activity in the neocortical slice.
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DOI：
10.1152/jn.1998.80.2.978
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发表时间：
1998-08
影响因子：
2.5
通讯作者：
Yang Tsau;Li Guan;Jian-Young Wu
中科院分区：
文献类型：
--
作者：
Yang Tsau;Li Guan;Jian-Young Wu
皮质局部回路在癫痫发生中很重要。使用电压敏感染料和快速成像来可视化成年大鼠新皮质切片中自发阵发性事件的启动。尽管自发阵发性事件可以从制剂中的任何地方开始，但光学成像显示所有自发事件都从一些有限的起始焦点开始并传播到整个制剂。超过数百个自发事件的多电极记录表明，每个制剂中通常有两个或三个起始焦点共存（n = 10）。这些焦点轮流占主导地位；在此期间，主要焦点引发了大多数自发性阵发性事件。焦点的主导焦点和焦点的动态重排表明自发性癫痫样事件的引发涉及局部多神经元过程，可能与增强的突触有关。
Cortical local circuitry is important in epileptogenesis. Voltage-sensitive dyes and fast imaging were used to visualize the initiation of spontaneous paroxysmal events in adult rat neocortical slices. Although spontaneous paroxysmal events could start from anywhere in the preparation, optical imaging revealed that all spontaneous events started at a few confined initiation foci and propagated to the whole preparation. Multielectrode recording over hundreds of spontaneous events revealed that often two or three initiation foci coexisted in each preparation (n = 10). These foci took turns being dominant; the dominant focus initiated the majority of the spontaneous paroxysmal events during that period. The dominant focus and dynamic rearrangement of foci suggest that the initiation of spontaneous epileptiform events involves a local multineuronal process, perhaps with potentiated synapses.