DISTINCT NEURAL CIRCUITS REFLECT SEX, SEXUAL MATURITY, AND REPRODUCTIVE STATUS IN RESPONSE TO STRESS IN DROSOPHILA MELANOGASTER
DISTINCT NEURAL CIRCUITS REFLECT SEX, SEXUAL MATURITY, AND REPRODUCTIVE STATUS IN RESPONSE TO STRESS IN DROSOPHILA MELANOGASTER
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DOI：
10.1016/j.neuroscience.2008.08.020
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发表时间：
2008-10-28
期刊：
影响因子：
3.3
通讯作者：
Matsuo, H.
中科院分区：
文献类型：
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作者：
Neckameyer, W. S.;Matsuo, H.
对哺乳动物系统的研究表明，不同大脑区域的递质信号在应对压力时会发生一系列变化，这些变化根据动物的年龄和基因组成以及压力类型而有所不同。在这里，我们利用果蝇（Drosophila melanogaster）的遗传易处理性，这是一个相对简单但有用的模型，可以阐明应激反应途径的保守组成部分。我们表明，蘑菇体和中央复合体（果蝇大脑内两个不同的解剖区域）内的结构调节对两种不同环境压力源的行为反应。暴露于这些压力源后行为输出的改变取决于动物的性别、性成熟度和生殖状态。这些参数还影响蘑菇体和/或中央复合体内携带特定缺陷的突变果蝇菌株是否改变了相对于野生型果蝇的应激反应。我们的结果表明，对于每个群体，独特的神经元子集被招募到应激反应回路中，并对运动行为和心脏功能产生不同的影响。这些数据还为成年昆虫大脑的神经可塑性提供了证据。 (C) 2008 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Studies in mammalian systems have shown an array of changes in transmitter signaling in diverse brain regions in response to stress, which differ depending on the age and genetic makeup of the animal, as well as the type of stress. Here, we exploit the genetic tractability of the fruit fly, Drosophila melanogaster, a comparatively simple but useful model in which to elucidate conserved components of stress response pathways. We show that structures within the mushroom bodies and central complex, two distinct anatomical regions within the Drosophila brain, modulate behavioral responses to two different environmental stressors. Modification of behavioral output after exposure to these stressors was dependent on the sex, sexual maturity, and reproductive status of the animal. These parameters also affected whether a mutant Drosophila strain carrying specific defects within the mushroom bodies and/or central complex modified its response to stress relative to wild-type flies. Our results suggest that for each population, unique subsets of neurons are recruited into the stress response circuitry and differentially affect locomotor behavior and cardiac function. These data also provide evidence for neural plasticity in the adult insect brain. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.