Risk Factors for Age-related Macular Degeneration
Risk Factors for Age-related Macular Degeneration
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DOI：
10.17925/eor.2011.05.02.143
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Emma J. Berrow;H. Bartlett;F. Eperjesi;J. Gibson
中科院分区：
文献类型：
--
作者：
Emma J. Berrow;H. Bartlett;F. Eperjesi;J. Gibson
虽然年龄相关性黄斑疾病（ARMD）的发病机制仍不完全清楚，遗传和环境因素的牵连。流行病学研究发现，ARMD的发展与许多潜在的风险因素之间存在矛盾。本文综述了与ARMD发展相关的可改变和不可改变的危险因素，并描述了危险因素与ARMD发展之间的潜在机制。年龄、吸烟和遗传因素似乎始终与ARMD风险增加相关。然而，衰老和遗传倾向目前无法改变，导致人们越来越关注其他可改变的因素如何降低ARMD的风险。
Although the pathogenesis of age-related macular disease (ARMD) is still not fully understood, genetic and environmental factors are implicated. Epidemiological studies have found conflicting findings between ARMD development and many potential risk factors. This review provides an up-to-date account of modifiable and non-modifiable risk factors associated with ARMD development, with potential mechanisms between risk factors and ARMD development described. Age, smoking and genetic factors appear to be consistently associated with an increased risk of developing ARMD. However, ageing and genetic disposition cannot be currently modified, leading to increased interest as to how other modifiable factors may reduce the risk of ARMD.