Scaffold targeting drug-resistant colon cancers
Scaffold targeting drug-resistant colon cancers
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DOI：
10.1021/jm070088s
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发表时间：
2007-05-03
影响因子：
7.3
通讯作者：
McAlpine, Shelli R.
中科院分区：
文献类型：
--
作者：
Otrubova, Katerina;McGuire, Kathleen L.;McAlpine, Shelli R.
我们已经确定了五个衍生物的天然产物sansalvamide A是有效的对多种耐药结肠癌细胞系。这些类似物与目前的结肠癌药物没有结构同源性，其细胞毒性水平与治疗其他癌症的现有药物相当，并且表现出对耐药结肠癌细胞系的选择性超过非癌细胞系。因此，我们已经建立了sansalvamide A作为治疗多重耐药结肠癌的特权结构。
We have identified five derivatives of the natural product sansalvamide A that are potent against multiple drug-resistant colon cancer cell lines. These analogs share no structural homology to current colon cancer drugs, are cytotoxic at levels on par with existing drugs treating other cancers, and demonstrate selectivity for drug-resistant colon cancer cell lines over noncancerous cell lines. Thus, we have established sansalvamide A as a privileged structure for treating multiple drug-resistant colon cancers.