Enhanced antitumor activity of a combination of MBD2‐antisense electrotransfer gene therapy and bleomycin electrochemotherapy
Enhanced antitumor activity of a combination of MBD2‐antisense electrotransfer gene therapy and bleomycin electrochemotherapy
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MBD2反义电转移基因疗法和博来霉素电化学疗法联合增强抗肿瘤活性
DOI：
10.1002/jgm.438
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
P. Bigey
中科院分区：
文献类型：
--
作者：
M. Ivanov;B. Lamrihi;M. Szyf;D. Scherman;P. Bigey
MBD 2是一种甲基化的DNA结合蛋白，以前曾被认为具有转录沉默以及DNA去甲基化酶活性。我们之前已经证明，MBD 2反义编码质粒的电转移可以抑制体内肿瘤生长。在这项研究中，我们测试了MBD 2-反义基因治疗和博来霉素化疗的组合是否与任何一种单药治疗相比具有增强的抗肿瘤作用。
MBD2 is a methylated DNA‐binding protein that has been previously suggested to have transcriptional silencing as well as DNA demethylase activities. We have previously shown that electrotransfer of an MBD2‐antisense encoding plasmid inhibits tumor growth in vivo. In this study we tested whether a combination of MBD2‐antisense gene therapy and bleomycin chemotherapy has an augmented antitumor effect in comparison with either monotherapy.
DOI：
10.1073/pnas.95.15.8829
发表时间：
1998-07-21
影响因子：
11.1
作者：
Lin, PN;Buxton, JA;Peters, KG
通讯作者：
Peters, KG