Human papillomavirus DNA positivity and seropositivity in rural Chinese men and women: a population-based cross-sectional study.
Human papillomavirus DNA positivity and seropositivity in rural Chinese men and women: a population-based cross-sectional study.
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中国农村男性和女性人乳头瘤病毒 DNA 阳性和血清阳性：基于人群的横断面研究。
DOI：
10.1038/srep26343
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发表时间：
2016-05-23
影响因子：
4.6
通讯作者：
Ke Y
中科院分区：
文献类型：
--
作者：
Liu F;Deng Q;Zhang C;Pan Y;Liu Y;He Z;Sun M;Liu M;Li J;Li X;Zhang C;Hang D;Ning T;Guo C;Liang Y;Xu R;Zhang L;Cai H;Ke Y
同时分析人乳头瘤病毒（HPV）DNA和血清学的数据以及在单一人群中的相关性是有限的。在中国农村招募的1603名男性和2187名女性中，采用多重血清学方法评估了针对细菌来源的HPV GST-L1融合蛋白的血清抗体，并采用基于PCR的测序方法评估了HPV DNA。少数受试者对HPV DNA和任何HPV的血清抗体呈双重阳性（6.6%的男性和3.1%的女性）。男性感染过任何一种HPV（DNA和/或抗体阳性）的比例高于女性（71.0% vs.65.2%，P < 0.001）。在女性中观察到生殖器HPV感染和HPV血清阳性的类型特异性相关性，但在男性中没有。在男性中发现终身性伴侣数量与致癌HPV DNA和/或抗体阳性之间呈正相关，但在女性中不存在。在762对夫妇中，一方存在HPV DNA和/或抗体与另一方存在相同的HPV类型呈正相关。这些发现可能反映了HPV感染的位点特异性自然过程，并进一步了解HPV的流行病学。
Data on simultaneous analysis of human papillomavirus (HPV) DNA and serology and the correlations within a single general population are limited. Among 1603 men and 2187 women enrolled from rural China, serum antibodies against bacterially derived GST-L1 fusion proteins of HPV were assessed with multiplexed serology and HPV DNA was evaluated with PCR-based sequencing. Few subjects were dually positive to HPV DNA and serum antibodies for any HPV (6.6% of men and 3.1% of women). The proportion of men ever having been infected with any HPV (DNA and/or antibody positive) was higher than that of women (71.0% vs. 65.2%, P < 0.001). Type-specific association was observed for genital HPV infection and HPV seropositivity among women but not among men. A positive correlation between the number of lifetime sexual partners and positivity for oncogenic HPV DNA and/or antibodies was found in men but was absent in women. Among 762 couples, the presence of HPV DNA and/or antibodies in one partner was positively associated with the identical HPV type in the other partner. These findings may reflect a site-specific natural course of HPV infection and further understanding of the epidemiology of HPV.