Block ionomer complexes as prospective nanocontainers for drug delivery
Block ionomer complexes as prospective nanocontainers for drug delivery
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DOI：
10.1016/j.jconrel.2006.06.030
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发表时间：
2006-09-28
影响因子：
10.8
通讯作者：
Kabanov, Alexander V.
中科院分区：
文献类型：
--
作者：
Oh, Kyung T.;Bronich, Tatiana K.;Kabanov, Alexander V.
纳米尺寸的环境响应性材料对于包括药物递送在内的各种应用具有特别的意义。以阳离子表面活性剂十六烷基三甲基溴化铵（HTAB）为模型化合物，与Pluronic和聚丙烯酸（PAA）的接枝梳型共聚物（Pluronic-PAA）在水溶液中混合，合成了嵌段离聚体复合物（BIC）。根据TEM，所得的BIC代表纳米级尺寸（50至100纳米）的球形颗粒。BIC在水性分散体中的稳定性取决于Pluronic分子中亲水性聚（环氧乙烷）和疏水性聚（环氧丙烷）链的长度以及所得复合物的表面电荷。后者通过改变BIC中Pluronic-PAA和HTAB的比例以及由于PAA链的可逆电离而改变pH来控制。低于pH 6.0的培养基的酸化导致BIC上出现强正电荷，其在细胞内环境中可引发此类BIC与细胞膜的相互作用。一个有效的增溶的模型疏水分子，苏丹III，和药物，依托泊苷，在这样的BIC证明与负载能力约6至15%重量的分散复合物。总的来说，这些BIC有望成为对环境敏感的药物纳米载体。(c)2006 Elsevier B. V.保留所有权利。
Nanosized environmentally responsive materials are of special interest for various applications, including drug delivery. Block ionomer complexes (BIC) composed of graft-comb copolymers of Pluronic and poly(acrylic acid) (Pluronic-PAA) and a model cationic surfactant, hexadecyltrimethylammonium bromide (HTAB), were synthesized by mixing the polymer and surfactant in aqueous media. According to TEM, the resulting BIC represented spherical particles of nanoscale size (50 to 100 nm). The stability of the BIC in the aqueous dispersion depended on the lengths of the hydrophilic poly(ethylene oxide) and hydrophobic poly(propylene oxide) chains in Pluronic molecules as well as on the surface charge of the resulting complexes. The latter was controlled by changing the ratio of the Pluronic-PAA and HTAB in the BIC and by changing the pH due to reversible ionization of the PAA chains. The acidification of the media below pH 6.0 resulted in the appearance of a strong positive charge on the BIC, which in the intracellular environment can trigger interaction of such BIC with the cell membranes. An efficient solubilization of a model hydrophobic molecule, Sudan III, and a drug, Etoposide, in such BIC was demonstrated with the loading capacities of about 6 to 15% by weight of the dispersed complex. Overall, these BIC wield a promise as environmentally responsive nanocarriers for pharmaceuticals. (c) 2006 Elsevier B.V. All rights reserved.