Maternal undernutrition increases arterial blood pressure in the sheep fetus during late gestation
Maternal undernutrition increases arterial blood pressure in the sheep fetus during late gestation
复制标题
DOI：
10.1111/j.1469-7793.2001.0561a.x
复制
发表时间：
2001-06-01
影响因子：
5.5
通讯作者：
McMillen, IC
中科院分区：
文献类型：
--
作者：
Edwards, LJ;McMillen, IC
1.我们研究了在妊娠最后30天内母体营养摄入量减少50%对动脉血压的影响以及对妊娠115-125天和135-145天（妊娠期= 147 +/-3天）的羊胎儿的动脉血压对血管紧张素II（AII）和血管紧张素转换酶（ACE）抑制剂卡托普利的反应.与对照动物相比，营养不良（UN）组的胎仔血糖浓度较低。然而，在妊娠115和145天之间，UN和对照组之间的胎儿血浆皮质醇或促肾上腺皮质激素（ACTH）浓度没有差异。在营养不良的前10天，与对照组相比，联合国组的母体血浆皮质醇浓度增加。妊娠115-125天，UN组胎儿动脉压也高于对照组，UN组平均动脉压与血浆ACTH浓度呈负相关（r =-0.62，P < 0.05）。在妊娠115-125天时，UN组的胎儿血压对增加剂量的血管紧张素IT的反应也高于对照组（P < 0.05）。在妊娠135 ~ 145天，未妊娠绵羊胎儿动脉血压升高，平均动脉血压与胎儿血浆皮质醇浓度相关.增加动脉血压和AII的反应，在胎儿的营养限制母羊的测量可能与胎儿暴露于皮质醇的行动，从胎盘转移后的第一个10天开始的限制喂养制度。
1. We have investigated the effect of a 50 % reduction in maternal nutrient intake during the last 30 days of pregnancy on arterial blood pressure and on arterial blood pressure responses to angiotensin II (AII) and the angiotensin converting enzyme (ACE) inhibitor captopril in the sheep fetus at 115-125 and at 135-145 days gestation (term = 147 +/- 3 days gestation).2. Fetal plasma glucose concentrations were lower in the undernourished (UN) group compared to the control animals. There was no difference, however, in fetal plasma cortisol or adrenocorticotrophic hormone (ACTH) concentrations between the UN and control groups between 115 and 145 days gestation.3. During the first 10 days of undernutrition, maternal plasma concentrations of cortisol M ere increased in the UN group compared to controls. At 115-125 days gestation, fetal arterial blood pressure was also higher in the UN group compared with controls and there was an inverse relationship (r = -0.62, P < 0.05) between mean arterial pressure and the fetal plasma concentrations of ACTH in the UN group. Fetal blood pressure responses to increasing doses of angiotensin IT were also higher (P < 0.05) in UN compared to control animals at 115-125 days gestation.4. Between 135 and 145 days gestation, fetal arterial blood pressure was increased in UN fetal sheep and mean arterial blood pressure was correlated with fetal plasma concentrations of cortisol.5. Increased arterial blood pressure and responsiveness to AII measured in the fetuses of nutrient-restricted ewes may be related in part to fetal exposure to the actions of cortisol derived from transplacental transfer during the first 10 days after the start of the restricted feeding regime.