Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO2 in Asthmatics.
Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO2 in Asthmatics.
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DOI：
10.4137/ehi.s15671
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发表时间：
2015
影响因子：
2.7
通讯作者：
Ameredes BT
中科院分区：
文献类型：
--
作者：
Reno AL;Brooks EG;Ameredes BT
二氧化硫（SO2）是广泛工业化地区的一种有问题的可吸入空气污染物，不仅在美国，而且在正在快速工业化的国家，如中国，它可能是哮喘急性发作的潜在触发因素。众所周知，哮喘患者对SO2的影响敏感;然而，这种敏感性增强的基础仍然不完全清楚。在2014年期间进行了PubMed检索，包括以下术语：哮喘、气道炎症、二氧化硫、IL-10、小鼠研究和人体研究。这项研究表明，SO2暴露的生物标志物，SO2对气道上皮细胞功能的影响，以及动物模型数据有助于我们了解身体对SO2的反应，以及SO2相关的过敏性炎症放大，以及由于化学刺激特性而可能促进神经源性炎症。虽然仍在寻求明确的答案，但这些领域包括关于吸入SO2的哮喘反应的重要考虑焦点。此外，与哮喘相关的IL-10缺乏可能是另一个与无法解决炎症和减轻SO2吸入引起的氧化应激相关的重要因素，支持哮喘患者易患SO2敏感性的观点，导致哮喘加重和气道功能障碍。
Sulfur dioxide (SO2) is a problematic inhalable air pollutant in areas of widespread industrialization, not only in the United States but also in countries undergoing rapid industrialization, such as China, and it can be a potential trigger factor for asthma exacerbations. It is known that asthmatics are sensitive to the effects of SO2; however, the basis of this enhanced sensitivity remains incompletely understood. A PubMed search was performed over the course of 2014, encompassing the following terms: asthma, airway inflammation, sulfur dioxide, IL-10, mouse studies, and human studies. This search indicated that biomarkers of SO2 exposure, SO2 effects on airway epithelial cell function, and animal model data are useful in our understanding of the body’s response to SO2, as are SO2-associated amplification of allergic inflammation, and potential promotion of neurogenic inflammation due to chemical irritant properties. While definitive answers are still being sought, these areas comprise important foci of consideration regarding asthmatic responses to inhaled SO2. Furthermore, IL-10 deficiency associated with asthma may be another important factor associated with an inability to resolve inflammation and mitigate oxidative stress resulting from SO2 inhalation, supporting the idea that asthmatics are predisposed to SO2 sensitivity, leading to asthma exacerbations and airway dysfunction.