Lung cancer and internal lung doses among plutonium workers at the Rocky Flats Plant:: A case-control study
Lung cancer and internal lung doses among plutonium workers at the Rocky Flats Plant:: A case-control study
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DOI：
10.1093/aje/kwh192
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发表时间：
2004-07-15
影响因子：
5
通讯作者：
Ruttenber, AJ
中科院分区：
文献类型：
--
作者：
Brown, SC;Schonbeck, MF;Ruttenber, AJ
作者对1951年至1989年在科罗拉多Rocky Flats工厂工作的一组工人进行了肺癌死亡率与累积肺内剂量之间关系的巢式病例对照研究。病例组（n = 180）与对照组（n = 720）在年龄、性别和出生年份上相匹配。用内照射剂量学模型计算了每个工人的钚、镅和铀同位素的肺年剂量。在几种不同的分析模型中，肺内累积剂量超过400毫希的工人患肺癌的风险升高。在高剂量下，剂量-反应关系不一致。将分析限制在受雇15-25年的工人中，产生了与剂量相关的统计学显著线性趋势（卡方= 67.2，p < 0.001），表明健康工人的存活效应很强。首次肺内给药时的年龄与肺癌死亡率之间的相关性具有统计学显著性（比值比= 1.05，95%置信区间：1.01，1.10）。未发现肺癌死亡率与累积外部穿透辐射剂量或石棉、铍、六价铬或镍累积暴露之间存在关联。
The authors conducted a nested case-control study of the association between lung cancer mortality and cumulative internal lung doses among a cohort of workers employed at the Rocky Flats Plant in Colorado from 1951 to 1989. Cases (n = 180) were individually matched with controls (n = 720) on age, sex, and birth year. Annual doses to the lung from plutonium, americium, and uranium isotopes were calculated for each worker with an internal dosimetry model. Lung cancer risk was elevated among workers with cumulative internal lung doses of more than 400 mSv in several different analytical models. The dose-response relation was not consistent at high doses. Restricting analysis to those employed for 15-25 years produced a statistically significant linear trend with dose (chi-square = 67.2, p < 0.001), suggesting a strong healthy worker survivor effect. The association between age at first internal lung dose and lung cancer mortality was statistically significant (odds ratio = 1.05, 95% confidence interval: 1.01, 1.10). No associations were found between lung cancer mortality and cumulative external penetrating radiation dose or cumulative exposures to asbestos, beryllium, hexavalent chromium, or nickel.